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Items for "protease inhibitors"

Anti-metastatic effects of serine protease inhibitors: animal models for analysis

To date, no effective adjuvant drug preventing the aggressive spread of tumour cells in late stages of cancer disease or at the time-point of primary tumour removal is available...

Keywords: Tiermodelle, Serinproteasen, Proteaseinhibitoren, Metastasierung, Screening, Lymphom, Fibrosarkom

01/2007 | Hämostaseologie, Schattauer

Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases

Aspartic proteases have emerged as targets for substrate-based inhibitor design due to their vital roles in the life cycles of the organisms that cause AIDS, malaria, leukemia, and other infectious diseases...

Keywords: AIDS, allophenylnorstatine, antiviral activity, HTLV-I, malaria, protease inhibitors

11/2004 | Biological Chemistry, Walter de Gruyter

Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B

Of seven human cystatins investigated, none inhibited the cysteine proteases staphopain A and B secreted by the human pathogen Staphylococcus aureus...

Keywords: cysteine peptidases, protease inhibitors, Staphylococcus aureus, virulence factors

04/2007 | Biological Chemistry, Walter de Gruyter

Impact of genetic polymorphisms on the risk of lipid disorders in patients on anti-HIV therapy

Active anti-HIV therapy can induce hypertriglyceridemia, low high-density lipoprotein (HDL) and insulin resistance, eventually accompanied by clinical lipodystrophy, associated loss of subcutaneous adipose tissue and an increase in abdominal adiposity...

Keywords: antiretroviral therapy, apolipoprotein A-V, apolipoprotein C-III, apolipoprotein E, dyslipidemia, HIV, lipodystrophy, pharmacogenomics, protease inhibitors, tumor necrosis factor-? (TNF?)