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Items for "protease inhibitor"

Cysteine cathepsins and caspases in silicosis

Silicosis is an occupational pneumoconiosis caused by inhalation of crystalline silica...

Keywords: Apoptosis, bronchoalveolar lavage, fibrosis, inflammation, protease, protease inhibitor

07/2006 | Biological Chemistry, Walter de Gruyter

Purification, characterization, and molecular gene cloning of an antifungal protein from Ginkgo biloba seeds

A novel basic protein with antifungal activity was isolated from the seeds of Ginkgo biloba and purified to homogeneity...

Keywords: antifungal protein, circular dichroism, Ginkgo biloba, ginkgo seeds, molecular cloning, protease inhibitor

03/2007 | Biological Chemistry, Walter de Gruyter

Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model

Recent data suggest proteases of the papain-like cysteine cathepsin family as molecular targets for cancer therapy...

Keywords: pharmacokinetics, protease inhibitor, therapy

08/2008 | Biological Chemistry, Walter de Gruyter

Inhibition of human ?-calpain by conformationally constrained calpastatin peptides

The 27-mer peptide CP1B-[1–27] derived from exon 1B of calpastatin stands out among the known inhibitors for ?- and m-calpain due to its high potency and selectivity...

Keywords: cysteine protease, macrolactamization, peptidomimetic, protease inhibitor