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Items for "prostate cancer"

Intraindividual comparison of [11C]acetate and [11C]choline PET for detection of metastases of prostate cancer

In a pilot trial we investigated whether significant differences in prostate cancer (PCA) imaging would be observed using [11C]acetate and [11C]choline positron emission tomography (PET). METHODS: Twelve patients were studied with both radiotracers...

Keywords: Azetat, Cholin, Positronenemissionstomographie, Prostatakarzinom

01/2003 | Nuklearmedizin, Schattauer
The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition

Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain...

Keywords: E-cadherin, EMT, KLK4, Migration, prostate cancer, PSA

06/2006 | Biological Chemistry, Walter de Gruyter
Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins

Human kallikrein 4 (hK4) is a member of the expanded family of human kallikreins, a group of 15 secreted proteases...

Keywords: cancer metastasis, extracellular matrix, human kallikrein 4, ovarian cancer, prognostic markers, prostate cancer, serine protease, serine protease inhibitors

06/2006 | Biological Chemistry, Walter de Gruyter
A sensitive proximity ligation assay for active PSA

Prostate-specific antigen (PSA) is a widely used marker for prostate cancer. The utility of PSA tests is limited by their inability to differentiate prostate cancer from non-malignant conditions such as benign prostatic hyperplasia and prostatitis...

Keywords: immunoassay, peptide, prostate cancer, prostate-specific antigen

06/2006 | Biological Chemistry, Walter de Gruyter
mRNA expression analysis of human kallikrein 11 (KLK11) may be useful in the discrimination of benign prostatic hyperplasia from prostate cancer after needle prostate biopsy

Kallikrein 11 (KLK11, TLSP, hippostatin) is a member of the human kallikrein gene family, which includes PSA, KLK2 and 12 other members, all localized on chromosome 19q13.4...

Keywords: free PSA, kallikreins, PCR, prostate, prostate cancer, prostate-specific antigen, PSA, serine proteases, tumor biomarkers

06/2006 | Biological Chemistry, Walter de Gruyter
Improved prostate cancer detection with a human kallikrein 11 and percentage free PSA-based artificial neural network

Human kallikrein 11 (hK11) was evaluated in a percentage free PSA-based artificial neural network (ANN) to reduce unnecessary prostate biopsies...

Keywords: artificial neural network (ANN), human kallikrein 11, prostate cancer, prostate-specific antigen

06/2006 | Biological Chemistry, Walter de Gruyter
Protein profiling as a diagnostic tool in clinical chemistry: a review

Serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) appears to be an important diagnostic tool for a whole range of diseases...

Keywords: biomarker, decision tree, diagnostic value, ovarian cancer, post-analytical conditions, pre-analytical conditions, prostate cancer, protein profiling, proteomics, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

12/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Comparison of the concentration of trace metals (Ni, Zn, Co, Cu and Se), Fe, vitamins A, C and E, and lipid peroxidation in patients with prostate cancer

The anticarcinogenic and antioxidant properties of vitamins A, C, E and pro- or antioxidant properties of trace metals have recently attracted increased attention...

Keywords: lipid peroxidation, prostate cancer, trace elements, vitamins

02/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Prostataspezifisches Antigen: Bedeutung für die Diagnostik des Prostatakarzinoms bei geriatrischen Patienten / Prostate-specific antigen: significance for the diagnosis of prostate cancer in geriatric patients

Zusammenfassung

Bei Männern der westlichen Welt ist das Prostatakarzinom die häufigste maligne Erkrankung...

Keywords: benigne Prostatahyperplasie, freies PSA, Gesamt-PSA, komplexiertes PSA, Präanalytik, prostataspezifisches Antigen, Prostatakarzinom, benign prostatic hyperplasia, complexed PSA, free PSA, pre-analytical procedures, prostate cancer, prostate-specific antigen, total PSA

02/2007 | LaboratoriumsMedizin, Walter de Gruyter