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Items for "prostate-specific antigen"

A sensitive proximity ligation assay for active PSA

Prostate-specific antigen (PSA) is a widely used marker for prostate cancer. The utility of PSA tests is limited by their inability to differentiate prostate cancer from non-malignant conditions such as benign prostatic hyperplasia and prostatitis...

Keywords: immunoassay, peptide, prostate cancer, prostate-specific antigen

06/2006 | Biological Chemistry, Walter de Gruyter
mRNA expression analysis of human kallikrein 11 (KLK11) may be useful in the discrimination of benign prostatic hyperplasia from prostate cancer after needle prostate biopsy

Kallikrein 11 (KLK11, TLSP, hippostatin) is a member of the human kallikrein gene family, which includes PSA, KLK2 and 12 other members, all localized on chromosome 19q13.4...

Keywords: free PSA, kallikreins, PCR, prostate, prostate cancer, prostate-specific antigen, PSA, serine proteases, tumor biomarkers

06/2006 | Biological Chemistry, Walter de Gruyter
Improved prostate cancer detection with a human kallikrein 11 and percentage free PSA-based artificial neural network

Human kallikrein 11 (hK11) was evaluated in a percentage free PSA-based artificial neural network (ANN) to reduce unnecessary prostate biopsies...

Keywords: artificial neural network (ANN), human kallikrein 11, prostate cancer, prostate-specific antigen

06/2006 | Biological Chemistry, Walter de Gruyter
Evolution of kallikrein-related peptidases in mammals and identification of a genetic locus encoding potential regulatory inhibitors

The human kallikrein locus on chromosome 19 consists of 15 genes encoding serine proteases...

Keywords: innate immunity, prostate-specific antigen, semenogelin, serine proteinase, species specificity, WFDC domain

03/2006 | Biological Chemistry, Walter de Gruyter
The measurement of complexed prostate-specific antigen has a better performance than total prostate-specific antigen

The aim of this study was to compare the diagnostic utility of complexed prostate-specific antigen (cPSA) with total PSA (tPSA) in screening for prostate cancer...

Keywords: cancer of the prostate, complexed/free prostate-specific antigen ratio, complexed prostate-specific antigen, free prostate-specific antigen, prostate-specific antigen, screening

09/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Prostataspezifisches Antigen: Bedeutung für die Diagnostik des Prostatakarzinoms bei geriatrischen Patienten / Prostate-specific antigen: significance for the diagnosis of prostate cancer in geriatric patients

Zusammenfassung

Bei Männern der westlichen Welt ist das Prostatakarzinom die häufigste maligne Erkrankung...

Keywords: benigne Prostatahyperplasie, freies PSA, Gesamt-PSA, komplexiertes PSA, Präanalytik, prostataspezifisches Antigen, Prostatakarzinom, benign prostatic hyperplasia, complexed PSA, free PSA, pre-analytical procedures, prostate cancer, prostate-specific antigen, total PSA

02/2007 | LaboratoriumsMedizin, Walter de Gruyter
An AKT activity threshold regulates androgen-dependent and androgen-independent PSA expression in prostate cancer cell lines

The androgen receptor (AR) plays an important role in early prostate cancer by activating transcription of a number of genes participating in cell proliferation and growth and cancer progression...

Keywords: AKT activity, androgen-independent, androgen receptor, prostate cancer, prostate-specific antigen

06/2008 | Biological Chemistry, Walter de Gruyter