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Items for "prion"

The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of ?-linked polyglucose

An inert polysaccharide scaffold identified as a 5–15% component of prion rods (PrP 27–30) is unambiguously distinguishable from the N-glycosyl groups and the GPI anchor of PrP, and consists predominantly of 1,4-linked glucose with some branching via 1,4,6-linked glucose...

Keywords: amyloid, corpora amylacea, glycogen, prion, scrapie, V-helix

11/2005 | Biological Chemistry, Walter de Gruyter

Detection of prion particles in samples of BSE and scrapie by fluorescence correlation spectroscopy without proteinase K digestion

A characteristic feature of prion diseases such as bovine spongiform encephalopathy (BSE) is the accumulation of a pathological isoform of the host-encoded prion protein, PrP...

Keywords: BSE diagnosis, 2D-FIDA, fluorescence correlation spectroscopy, prion, proteinase, scrapie, single particle detection

01/2006 | Biological Chemistry, Walter de Gruyter

Interaction of the cellular prion protein with raft-like lipid membranes

Conversion of the cellular isoform of the prion protein (PrP^C) into the disease-associated isoform (PrP^Sc) plays a key role in the development of prion diseases...

Keywords: Biacore, GPI anchor, prion, PrPC, surface plasmon resonance

01/2007 | Biological Chemistry, Walter de Gruyter

Paired helical filaments contain small amounts of cholesterol, phosphatidylcholine and sphingolipids

By using qualitative and quantitative high-performance thin layer chromatography (hpTLC) we found lipids associated with purified Alzheimer's (AD) paired helical filaments (PHF) in an amount of 1.4±0.2% of the total anhydrous mass...

Keywords: amyloid, cholesterol, hpTLC, lipid rafts, paired helical filaments, prion