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Items for "preterm labor"

Feasibility of a randomized controlled trial testing nifedipine vs. placebo for the treatment of preterm labor

Aims: Nifedipine is believed to be a superior tocolytic agent on the basis of efficacy and side-effect profile, but was never prospectively evaluated in a placebo-controlled randomized clinical trial (RCT)...

Keywords: Feasibility study, nifedipine, preterm labor, randomized controlled trial, tocolysis

04/2007 | Journal of Perinatal Medicine, Walter de Gruyter

Atosiban versus usual care for the management of preterm labor

Objective: To compare the efficacy of atosiban with usual management of threatened preterm labor.

Methods: In this prospective, open-label, randomized controlled trial, women admitted to the hospital in threatened preterm labor (between 24 and 34 weeks' gestation) were randomized to receive atosiban or usual care (?-agonists, calcium channel blockers, magnesium sulphate, or any other tocolytic, alone or in combination, and/or bed rest).

Results: In women randomized to receive atosiban (n=295) or usual care (n=290), significantly more women receiving atosiban remained undelivered at 48 h with no alternative tocolytic compared with usual care (77.6% vs...

Keywords: Atosiban, preterm labor, tocolysis, tocolytic therapy

08/2007 | Journal of Perinatal Medicine, Walter de Gruyter

Fetal membrane inflammatory cytokines: a switching mechanism between the preterm premature rupture of the membranes and preterm labor pathways

Inflammatory cytokines are involved in both preterm labor and preterm premature of the membranes pathways; however, the interaction between TNF-? and its receptors may dictate the clinical outcome of pregnancy.

Keywords: cytokines, preterm labor, prematurity, PROM, MMPs, Apoptosis

09/2004 | Journal of Perinatal Medicine, Walter de Gruyter

Global approach to perinatal medicine: functional genomics and proteomics

Functional genomics (transcriptomics and proteomics) is a global, systematic and comprehensive approach to the identification and description of the processes and pathways involved in normal and abnormal physiological states...

Keywords: biomarkers, DNA microarrays, functional genomics, Mass spectrometry, perinatal medicine, pre-eclampsia, preterm labor, proteomics, transcriptomics, two-dimensional electrophoresis

01/2005 | Journal of Perinatal Medicine, Walter de Gruyter

The epidemiology of preterm labor – a global perspective

The major burden of preterm birth is in the developing world, where much of the death and morbidity is secondary to infectious diseases such as malaria, HIV, tuberculosis and intestinal parasites...

Keywords: Bacterial vaginosis, ethnic group, HIV, malaria, pregnancy hypertension, preterm labor

07/2005 | Journal of Perinatal Medicine, Walter de Gruyter

Anaphylatoxins in preterm and term labor

Objective: The complement system plays a central role in the first line of defense against invading pathogens, and its activation involves the release of potent pro-inflammatory mediators such as anaphylatoxins C3a, C4a and C5a...

Keywords: parturition, human labor, preterm labor, intra-amniotic infection, anaphylatoxin, C3a, C4a, C5a

07/2005 | Journal of Perinatal Medicine, Walter de Gruyter

The effect of betamethasone administration on uterine motility in pregnancy. A prospective study using four-channel tocography

We monitored 30 patients before and after betamethasone prophylaxis using four-channel tocography to evaluate if betamethasone therapy in the case of imminent preterm delivery increases uterine activity...

Keywords: betamethasone, four-channel tocography, preterm labor, respiratory distress syndrome (RDS), uterine motility

04/2006 | Journal of Perinatal Medicine, Walter de Gruyter

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