Items for "platelets"

Tissue factor-positive microparticles: Cellular origin and association with coagulation activation in patients with colorectal cancer

The pathogenesis of hypercoagulability in cancer is not entirely understood. We hypothesized that in cancer patients circulating tissue factor-positive microparticles (TF + MPs) are increased and associated with hemostatic system activation...

Keywords: Cancer, microparticles, Tissue factor, hemostasis, platelets

The role of platelets for the pathophysiology of acute coronary syndromes

Cardiovascular diseases, especially ischaemic heart disease, are actually the most frequent causes of death in the Western world and represent a central challenge for modern research and medicine...

Keywords: Akutes Koronarsyndrom, Atherosklerose, Thrombozyten, Myokardinfarkt

Utility of a whole blood single platelet counting assay to monitor the effects of tirofiban in patients with acute coronary syndromes scheduled for coronary intervention

This study aimed to establish the utility of a whole-blood singleplatelet counting (WBSPC) assay, a measure of microaggregation, in monitoring the effects of tirofiban, comparing this with optical aggregometry (OA) and the Ultegra TRAP cartridge system (UTC), measures of macroaggregation...

Keywords: platelets, tirofiban, whole blood single platelet count, microaggregation.

Truncated and microparticle-free soluble tissue factor bound to peripheral monocytes preferentially activate factor VII

Soluble plasma tissue factor (TF) circulates in picomolar concentrations in healthy individuals and increases in a wide spectrum of diseases...

Keywords: Soluble tissue factor, monocytes, platelets, thrombin

Local delivery of soluble platelet collagen receptor glycoprotein VI inhibits thrombus formation in vivo

Platelet-mediated thrombus formation at the site of vascular injury is a major trigger for thrombo-ischemic complications after coronary interventions...

Keywords: angioplasty, glycoprotein VI, platelets, thrombosis, collagen

Group B streptococcus isolates from septic patients and healthy carriers differentially activate platelet signaling cascades

Infection with group B streptococcus (GBS) is the most common cause of early onset neonatal sepsis in many countries, leading to neonatal morbidity and mortality...

Keywords: Group B streptococcus, platelets, Fcγ RIIA, MAPK, PKC

Potential role of activated platelets in homing of human endothelial progenitor cells to subendothelial matrix

Endothelial progenitor cells (EPCs) mobilize from the bone marrow in response to tissue injury and participate in vascular repair...

Keywords: platelets, endothelial progenitor cells, Interaction

Immunohistochemistry of thrombi following iliac venous stenting: A novel model of venous thrombosis

Stenting has become a common intervention for venous occlusive disease. Little is known regarding the composition of venous thrombi complicating stent placement...

Keywords: Venous thrombosis, vascular stents, platelets

Platelet activation and high tissue factor level predict acute stent thrombosis in pig coronary arteries: Prothrombogenic response of drug-eluting or bare stent implantation within the first 24 hours

Increased thrombogenicity of drug-eluting stents (DESs) has recently been reported. The aim of the present study was to investigate the prothrombogenic effect of DESs and Bare stents, and determine factors predictive of acute stent thrombosis (AST) in preclinical experiments using new stent design or coating...

Keywords: platelets, stents,thrombosis, coronary circulation, Tissue factor

Tissue factor-enriched vesicles are taken up by platelets and induce platelet aggregation in the presence of factor VIIa

We investigated the interactions of vesicles containing human tissue factor (TF) with platelets and evaluated responses induced by rFVIIa using standard aggregometry, ultrastructural and flow-cytometry techniques...

Keywords: platelets, Tissue factor, vesicles, traffic, rFVIIa

Plasma membrane Ca2+-ATPase associates with CLP36, -actinin and actin in human platelets

The plasma membrane Ca2+-ATPase (PMCA) plays an essential role in maintaining low cytosolic Ca2+ in resting platelets...

Keywords: platelets, plasma membrane Ca2+-ATPase, calcium signaling, filopodia

Diagnostic approach to inherited bleeding disorders

The appropriate development of hemostasis encompasses a delicate equilibrium between anti- and prothrombotic forces developing during three distinct phases (primary hemostasis, coagulation and fibrinolysis) that are closely linked to each other and precisely regulated to close vessel wounds, promote vascular healing and maintain vessel patency...

Keywords: coagulation testing, Hemophilia, inherited bleeding disorders, laboratory testing, platelets

Thrombocytopoiesis in healthy term newborns

Aims: Thrombocytopoiesis was investigated in term newborns determining thrombopoietin (TPO), reticulated platelets (PLRET) and blood platelets (PLT) in relation to gender.

Patients and methods: The study was undertaken on 72 healthy term newborns, 33 girls and 39 boys...

Keywords: Newborns, platelets, reticulated platelets, thrombopoietin

Aspirin-Resistenz / Aspirin resistance

Acetylsalicylsäure (ASS) ist Grundlage der thrombozytenfunktionshemmenden Prävention atherothrombotischer Ereignisse...

Keywords: Acetylsalicylsäure, Cyclooxygenase, Thromboxan A2, Thrombozyten, Thrombozytenaggregation, Aspirin, platelet aggregation, platelets, thromboxane A2

Thrombozytenaktivität und Thrombozyten-Leukozyten-Konjugate als Marker in der Sportmedizin Platelet activity and platelet-leukocyte conjugate formation as markers in sports medicine

Thrombozyten haben eine zentrale Bedeutung bei der Arteriosklerose und auch bei akuten thrombotischen Ereignissen...

Keywords: Aggregate, CD62p, Konjugate, PAC-1, Thrombozyten, TRAP (thrombin-receptor activating peptide), aggregates, conjugates, platelets