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Items for "platelet aggregation"

A novel fibrinogen B chain frameshift mutation in a patient with severe congenital hypofibrinogenaemia

Congenital afibrinogenemia and severe hypofibrinogenemia are severe bleeding disorders characterized by either undetectable or very low levels of fibrinogen in patients plasma and platelets...

Keywords: Congenital hypofibrinogenemia / afibrinogenemia, fibrinogen/fibrin, gene mutation, platelet aggregation

06/2006 | Thrombosis and Haemostasis, Schattauer

Comparison of VASP-phosphorylation assay to light-transmission aggregometry in assessing inhibition of the platelet ADP P2Y 12 receptor

There is need to improve platelet function testing to monitor the response to antiplatelet drugs. We compared flow-cytometric analysis of intraplatelet vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) to light-transmission aggregometry for the detection of drug-induced in-vitro inhibition of the platelet P2Y 12 ADP receptor on 22 healthy subjects (10 males, 12 females, 28.5 6.6 years)...

Keywords: VASP phosphorylation, platelet aggregation, P2Y12 ADP receptor antagonist, cangrelor

12/2006 | Thrombosis and Haemostasis, Schattauer

Multiple electrode aggregometry: A new device to measure platelet aggregation in whole blood

Several methods are used to analyse platelet function in whole blood. A new device to measure whole blood platelet aggregation has been developed, called multiple electrode platelet aggregometry (MEA)...

Keywords: anticoagulation, multiple electrode aggregometry, platelet aggregation, single platelet counting

12/2006 | Thrombosis and Haemostasis, Schattauer

Genetic strain differences in platelet aggregation and thrombus formation of laboratory rats

Rats are employed to investigate the role of platelets in thrombus formation under flow conditions in vivo and to evaluate the pre-clinical potential of antiplatelet drugs...

Keywords: platelet aggregation, rat, strain difference, thrombus formation

04/2007 | Thrombosis and Haemostasis, Schattauer

Aspirin-Resistenz / Aspirin resistance

Zusammenfassung

Acetylsalicylsäure (ASS) ist Grundlage der thrombozytenfunktionshemmenden Prävention atherothrombotischer Ereignisse...

Keywords: Acetylsalicylsäure, Cyclooxygenase, Thromboxan A2, Thrombozyten, Thrombozytenaggregation, Aspirin, platelet aggregation, platelets, thromboxane A2

10/2006 | LaboratoriumsMedizin, Walter de Gruyter

Utility of PFA-100^® closure time vs. optical aggregometry in assessing the efficacy of platelet membrane glycoprotein IIb/IIIa antagonists in vitro

Background: Closure time measured by a platelet function analyser (PFA-100^®) was examined for its usefulness in assessing the efficacy of platelet membrane glycoprotein IIb/IIIa antagonists in vitro, and was compared to optical platelet aggregometry.

Methods: Three known glycoprotein IIb/IIIa antagonists [H-Arg-Gly-Asp-Ser-OH (RGDS), tirofiban and eptifibatide] and six new peptidomimetic glycoprotein IIb/IIIa antagonists (DKT-59, DPS-172, SMA-101, SMA-104, SMA-179 and SKN-191) were assessed...

Keywords: closure time, glycoprotein IIb/IIIa antagonist, peptidomimetic, platelet aggregation, platelet function analyser

11/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

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