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Items for "Platelet"

A role for immunoglobulin G in donor-specific Streptococcus sanguis-induced platelet aggregation

There is increasing evidence for a relationship between bacterial infections and several cardiovascular disorders...

Keywords: Platelet, Fc ? RIIA, polymorphisms, IgG, Streptococcus sanguis

00/0000 | Thrombosis and Haemostasis, Schattauer
Warm-up exercise suppresses platelet-eosinophil/neutrophil aggregation and platelet-promoted release of eosinophil/neutrophil oxidant products enhanced by severe exercise in men

Heterotypic platelet-eosinophil/neutrophil aggregation and subsequent release of eosinophil/neutrophil oxidant products contribute to pathogenesis of conditions such as asthma and inflammatory bowel diseases...

Keywords: Warm-up, eosinophil, Platelet, inflammation, thrombosis

03/2006 | Thrombosis and Haemostasis, Schattauer
Analysis of SAGE data in human platelets: Features of the transcriptome in an anucleate cell

A comprehensive SAGE (serial analysis of gene expression) library of purified human platelets was established...

Keywords: Platelet, Transcriptome, SAGE, signaling pathway, post-transcriptional regulation, RNA element, Gene Ontology

04/2006 | Thrombosis and Haemostasis, Schattauer
Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers

Thromboxane A2 receptor (TP) is an important actor in vascular physiology and plays a crucial role in the platelet activation process...

Keywords: genetics, Platelet, polymorphisms, thromboxane, TP

09/2006 | Thrombosis and Haemostasis, Schattauer
Plasma glycoprotein V levels in the general population: Normal distribution, associated parameters and implications for clinical studies

Soluble glycoproteinV (sGPV) is a new plasma marker of thrombosis released from the platelet surface by thrombin...

Keywords: Glycoprotein V, GPV, Platelet, thrombosis marker

10/2006 | Thrombosis and Haemostasis, Schattauer
Rational humanization of the powerful antithrombotic anti-GPIba antibody: 6B4

Fab-fragments of the monoclonal antibody 6B4, raised against human glycoprotein Iba (GPIba), have a powerful antithrombotic effect in baboons by blocking the GPIba binding site for von Willebrand factor (VWF), without significant prolongation of the skin bleeding time...

Keywords: Antithrombotic, computer modeling, humanization, glycoprotein Ib, Platelet

11/2006 | Thrombosis and Haemostasis, Schattauer
Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets

Platelet microparticles (PMPs) are small vesicles released from blood platelets upon activation. The procoagulant activity of PMPs has been previously mainly characterized by their ability to bind coagulation factors VIII and Va in reconstructed systems...

Keywords: Platelet, PMPs, procoagulant activity, spatial dynamics of coagulation, thrombin generation, factor X, phosphatidylserine, CD-61, CD-62P

03/2007 | Thrombosis and Haemostasis, Schattauer
N-Ethylmaleimide-sensitive factor: a redox sensor in exocytosis

Vascular injury triggers endothelial exocytosis of granules, releasing pro-inflammatory and pro-thrombotic mediators into the blood...

Keywords: endothelial cell, Hydrogen Peroxide, nitric oxide, peroxynitrite, Platelet, reactive oxygen species, superoxide, Weibel-Palade bodies

10/2006 | Biological Chemistry, Walter de Gruyter
Novel molecular defect in the platelet ADP receptor P2Y12 of a patient with haemorrhagic diathesis

Background: The platelet adenosine 5'-diphosphate (ADP) receptor P2Y12 plays a crucial role in haemostasis...

Keywords: adenosine 5?-diphosphate (ADP) receptor, bleeding, mutation, P2Y12, Platelet, thrombus

02/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Premature labor: a state of platelet activation?

Objective: This study was undertaken to determine whether premature labor is associated with changes in the maternal plasma concentration of soluble CD40 ligand (sCD40L), a marker of platelet activation.

Methods: A cross-sectional study included patients in the following groups: 1) non-pregnant (n=21); 2) normal pregnancy (n=71); 3) normal pregnancy at term with (n=67) and without labor (n=88); 4) preterm labor (PTL) with intact membranes (n=136) that was divided into the following sub-groups: 4a) PTL who delivered at term (n=49); 4b) PTL without intra-amniotic infection and/or inflammation (IAI) who delivered preterm (n=54); and 4c) PTL with IAI who delivered preterm (n=33)...

Keywords: Coagulation, inflammation, labor, prematurity, Platelet, thrombin, sCD40L

09/2008 | Journal of Perinatal Medicine, Walter de Gruyter