Items for "platelet-activating factor acetylhydrolase"

Paraoxonase and platelet-activating factor acetylhydrolase activities in lipoproteins of ?-thalassemia/hemoglobin E patients

Background: Iron-induced oxidative stress may be implicated in the alteration of the lipoprotein-associated antioxidant enzymes paraoxonase 1 (PON1) and platelet-activating factor acetylhydrolase (PAF-AH), leading to atherosclerosis-related vascular complication in patients with ?-thalassemia hemoglobin E (?-thal/Hb E).

Methods: Plasma and lipoprotein enzyme activities of PON1 and PAF-AH were studied in 13 mild to moderate and 15 severe cases of ?-thal/Hb E in comparison with 15 normal subjects.

Results: PON1 activity was significantly reduced in association with oxidative stress in the patients...

Keywords: lipoprotein, oxidative stress, paraoxonase, platelet-activating factor acetylhydrolase, ?-thalassemia