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Items for "plasminogen activator inhibitor-1"

Successful silencing of plasminogen activator inhibitor-1 in human vascular endothelial cells using small interfering RNA

Clinical as well as experimental evidence suggests that vascular overexpression of plasminogen activator inhibitor (PAI)-1, the primary physiological inhibitor of both urokinase and tissuetype plasminogen activator, may be involved in the pathophysiology of atherosclerosis and cardiovascular disease...

Keywords: Cell adhesion, fibrinolysis, Endothelial cells, plasminogen activator inhibitor-1, RNA interference

05/2006 | Thrombosis and Haemostasis, Schattauer
Evaluation of pre-analytical, demographic, behavioural and metabolic variables on fibrinolysis and haemostasis activation markers utilised to assess hypercoagulability

Background: Measurement of some haemostatic factors and products formed during activation of haemostasis seems to be promising in the determination of hypercoagulability.

Methods: The fibrinolytic variables euglobulin clot lysis time, tissue-type plasminogen activator, plasminogen activator inhibitor-1 and the haemostasis activation markers prothrombin fragment 1+2, thrombin-antithrombin complex and D-dimer were determined in 101 apparently healthy men and women aged 20–92 years (58ą18 years, meanąSD) to establish variability due to several demographic, behavioural and metabolic factors.

Results: None of the fibrinolytic variables were affected by smoking, while tissue-type plasminogen activator antigen was significantly lower in women compared to men...

Keywords: D-dimer, fibrinolysis, plasminogen activator inhibitor-1, prothrombin fragment 1+2, thrombin-antithrombin complex, Tissue-type plasminogen activator

01/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter