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Items for "plasma kallikrein"

Expression of the plasma prekallikrein gene: utilization of multiple transcription start sites and alternative promoter regions

The plasma prekallikrein gene is expressed in many different human tissues at distinctly different levels and therefore tissue-specific control of the gene transcription is likely...

Keywords: alternative promoter, alternative transcription start site, Inr element, plasma kallikrein, plasma prekallikrein, promoter activity, TATA box, transcription start site, 5?-untranslated region heterogeneity

02/2005 | Biological Chemistry, Walter de Gruyter

Cellular expression of plasma prekallikrein in human tissues

Plasma prekallikrein (PPK) is synthesised in hepatocytes and secreted into the blood, where it participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation...

Keywords: cellular functions of plasma prekallikrein, kidney, KLKB1, pancreas, plasma kallikrein, plasma prekallikrein

09/2007 | Biological Chemistry, Walter de Gruyter

Novel expression of kallikreins, kallikrein-related peptidases and kinin receptors in human pleural mesothelioma

Malignant mesothelioma is an aggressive cancer of the pleura that is causally related to exposure to asbestos fibres...

Keywords: kallikrein related-peptidases, kinin B1 and B2 receptors, plasma kallikrein, pleural mesothelioma, tissue kallikrein

11/2007 | Biological Chemistry, Walter de Gruyter

Expression of tissue and plasma kallikreins and kinin B₁ and B₂ receptors in lung cancer

Tissue kallikrein (hK1) and plasma kallikrein (PK, hKB1) are serine proteases that produce biologically active kinin peptides from endogenous kininogen substrates...

Keywords: cancer biomarkers, kinin B1 and B2 receptors, lung carcinoma subtypes, plasma kallikrein, tissue kallikrein

09/2008 | Biological Chemistry, Walter de Gruyter