Items for "phospholipase A2"

Secretory phospholipase A₂ activity and release kinetics of vascular tissue remodelling biomarkers after coronary artery bypass grafting with and without cardiopulmonary bypass

Background: Cardiopulmonary bypass (CPB) has long been recognised as a main cause of a postoperative complex systemic inflammatory response after coronary artery bypass grafting (CABG).

Methods: We determined the kinetics of peripheral blood release of the novel inflammatory biomarkers secretory phospholipase A₂ (sPLA₂), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) during the first 6 days following surgery in 16 patients undergoing CABG with (on-pump, n=9) or without (off-pump, n=7) CPB...

Keywords: cardiopulmonary bypass, coronary artery bypass grafting, inflammation, matrix metalloproteinases, phospholipase A2