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Items for "pharmacokinetics"

A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - Part I: Pharmacological characterization

We have discovered a novel small-molecule (3-phosphinoylpropionic acid) inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa), BX 528, which had an IC 50 of 2 nM in an enzymatic assay and 50 nM in an in-vitro clot lysis assay, with 3,500- to 35,000-fold selectivity against other carboxypeptidases, such as CPN, CPZ and CPD, and 5- and 12-fold selectivity against CPE (CPH) and CPB, respectively...

Keywords: TAFI, carboxypeptidases, potency, selectivity, safety, pharmacokinetics

01/2007 | Thrombosis and Haemostasis, Schattauer

Anticoagulant and anti-platelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, and acetylsalicylic acid

The pharmacokinetics, pharmacodynamics and safety of the direct factor Xa inhibitor, otamixaban, with and without concomitant acetylsalicylic acid (ASA) were investigated in healthy volunteers...

Keywords: Acetylsalicylic acid, Coagulation, factor Xa, pharmacokinetics, pharmacodynamics, o

00/0000 | Thrombosis and Haemostasis, Schattauer

A multi-dose pharmacokinetic study of dalteparin in haemodialysis patients

Low-molecular-weight heparins undergo renal elimination, and therefore the proper dosing in hemodialysis (HD) patients is unclear...

Keywords: Dalteparin, Hemodialysis, Low-molecular-weight heparin, pharmacokinetics

12/2006 | Thrombosis and Haemostasis, Schattauer

A simple isocratic HPLC assay to determine linezolid concentrations in different biomatrices for in vivo and in vitro studies

Background: Linezolid is an important therapeutic option for the treatment of infections caused by multiresistant Gram-positive bacteria such as vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA)...

Keywords: analytics, pharmacodynamics, pharmacokinetics, therapeutic drug monitoring, tissues

08/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Therapeutisches Drug Monitoring in der Pädiatrie / Therapeutic drug management in pediatric patients

Zusammenfassung

Theoretische Überlegungen und praktische Erfahrungen belegen, dass korrekt bestimmte und richtig interpretierte Bestimmungen von Medikamenten-Konzentrationen im Blut von Patienten (Therapeutisches Drug Monitoring – TDM) die Patientenversorgung bei gleichzeitiger Kostenreduktion verbessern können.

Viele Publikationen belegen die Notwendigkeit einer individuellen Medikamenten-Dosierung bei Kindern und Erwachsenen; wenige, jedoch überzeugende Studien sprechen für die Kosteneffizienz...

Keywords: Bayessche adaptive Kontrollstrategie, Pädiatrie, Pharmakodynamik, Pharmakokinetik, Populationsmodell, therapeutisches Drug Management, therapeutisches Drug Monitoring (TDM), Zielkonzentration, Bayesian adaptive control, Pediatrics, pharmacodynamics, pharmacokinetics, population modeling, target concentration, therapeutic drug management, therapeutic drug monitoring (TDM)

02/2007 | LaboratoriumsMedizin, Walter de Gruyter

Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model

Recent data suggest proteases of the papain-like cysteine cathepsin family as molecular targets for cancer therapy...

Keywords: pharmacokinetics, protease inhibitor, therapy

08/2008 | Biological Chemistry, Walter de Gruyter

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