Active anti-HIV therapy can induce hypertriglyceridemia, low high-density lipoprotein (HDL) and insulin resistance, eventually accompanied by clinical lipodystrophy, associated loss of subcutaneous adipose tissue and an increase in abdominal adiposity...
Keywords: antiretroviral therapy, apolipoprotein A-V, apolipoprotein C-III, apolipoprotein E, dyslipidemia, HIV, lipodystrophy, pharmacogenomics, protease inhibitors, tumor necrosis factor-? (TNF?)
07/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterPharmacogenetics and pharmacogenomics deal with genetically determined variations in how individuals respond to drugs...
Keywords: adverse drug reactions, CYP2D6, CYP2C9, CYP2C19, genetic polymorphism, pharmacogenetics, pharmacogenomics, therapeutic drug monitoring, thiopurine S-methyltransferase (TPMT), uridine diphosphate glucuronosyltransferase (UGT1A1)
07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter“Personalized medicine” based on an individual’s genetic makeup is slowly becoming a reality as pharmacogenomics moves from the research setting to the clinical laboratory...
Keywords: genotyping, pharmacogenomics, technologies
11/2004 | Clinical Chemical Laboratory Medicine, Walter de GruyterThis workshop discussed the use of pharmacogenomics knowledge in clinical practice...
Keywords: education, industry, Personalized Medicine, pharmacogenomics, regulatory aspects
07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter