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Items for "pharmacogenetics"

Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of the pyrimidine bases uracil and thymine, as well as of the widely used chemotherapeutic drug 5-fluorouracil (5FU)...

Keywords: dihydropyrimidine dehydrogenase, DPYD, 5-fluorouracil, pharmacogenetics, pyrimidines, thymine, uracil

04/2005 | Biological Chemistry, Walter de Gruyter

Pharmacogenomics and adverse drug reactions in diagnostic and clinical practice

Pharmacogenetics and pharmacogenomics deal with genetically determined variations in how individuals respond to drugs...

Keywords: adverse drug reactions, CYP2D6, CYP2C9, CYP2C19, genetic polymorphism, pharmacogenetics, pharmacogenomics, therapeutic drug monitoring, thiopurine S-methyltransferase (TPMT), uridine diphosphate glucuronosyltransferase (UGT1A1)

07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

The influence of genetic polymorphisms of cytochrome P450 3A5 and ABCB1 on starting dose- and weight-standardized tacrolimus trough concentrations after kidney transplantation in relation to renal function

Background: Cytochrome P450 3A5 (CYP3A5) and ABCB1 polymorphisms have been shown to influence tacrolimus (Tc) blood concentrations in the stable phase after organ transplantation...

Keywords: kidney transplantation, pharmacogenetics, renal function, tacrolimus

10/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Richtlinie: Labormedizinische Diagnostik bei der Therapie mit TPMT (Thiopurin-S-Methyltransferase)-abhängigen Pharmaka. Guidelines for the laboratory management of thiopurine drug therapy

Zusammenfassung

Zusammenfassung Thiopurine (Azathioprin, 6-Mercaptopurin, 6-Thioguanin) werden als Immunsuppressiva und Zytostatika eingesetzt...

Keywords: Azathioprin, Drug-Monitoring, Genotyp-Phänotyp Korrelation, Immmunsuppressiva, 6-Mercaptopurin, Nebenwirkungen, Pharmakogenetik, Thioguanin, Thiopurine, Thiopurin-S-Methyltransferase (TPMT), TPMT-Defizienz, TPMT-Polymorphismen, adverse effects, azathioprine, drug monitoring, genotype-phenotype correlation, immunosuppressive agents, 6-mercaptopurine (6-MP), pharmacogenetics, thioguanine, thiopurine methyltransferase (TPMT), thiopurines, TPMT-deficiency, TPMT-polymorphisms

12/2004 | LaboratoriumsMedizin, Walter de Gruyter

Dihydropyrimidindehydrogenase-Mangel und Fluorpyrimidin-Toxizität / Dihydropyrimidine dehydrogenase deficiency and fluoropyrimidine toxicity

Zusammenfassung

Der Dihydropyrimidindehydrogenase (DPD)-Mangel in heterozygoter Ausprägung ist ein pharmakogenetisches Syndrom, welches bei Fluorpyrimidinexposition im Rahmen einer Chemotherapie eine Prädisposition für verstärkte Toxizität darstellen kann...

Keywords: Dihydropyrimidindehydrogenase, Fluorpyrimidin, Pharmakogenetik, Übersicht, dihydropyrimidine dehydrogenase, fluoropyrimidine, pharmacogenetics, Review

12/2006 | LaboratoriumsMedizin, Walter de Gruyter

Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population

Background: Thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme involved in the metabolism of thiopurine drugs...

Keywords: enzyme activity, haplotype analysis, pharmacogenetics, thiopurine methyltransferase (TPMT)

07/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

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