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Items for "pharmacodynamics"

Anticoagulant and anti-platelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, and acetylsalicylic acid

The pharmacokinetics, pharmacodynamics and safety of the direct factor Xa inhibitor, otamixaban, with and without concomitant acetylsalicylic acid (ASA) were investigated in healthy volunteers...

Keywords: Acetylsalicylic acid, Coagulation, factor Xa, pharmacokinetics, pharmacodynamics, o

00/0000 | Thrombosis and Haemostasis, Schattauer

Biodistribution of covalent antithrombin-heparin complexes

We have developed a covalent antithrombin-heparin (ATH) complex with advantages compared to non-covalent antithrombin:heparin (AT:H) mixtures...

Keywords: Antithrombin, heparin, pharmacodynamics

04/2006 | Thrombosis and Haemostasis, Schattauer

A simple isocratic HPLC assay to determine linezolid concentrations in different biomatrices for in vivo and in vitro studies

Background: Linezolid is an important therapeutic option for the treatment of infections caused by multiresistant Gram-positive bacteria such as vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA)...

Keywords: analytics, pharmacodynamics, pharmacokinetics, therapeutic drug monitoring, tissues

08/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Therapeutisches Drug Monitoring in der Pädiatrie / Therapeutic drug management in pediatric patients

Zusammenfassung

Theoretische Überlegungen und praktische Erfahrungen belegen, dass korrekt bestimmte und richtig interpretierte Bestimmungen von Medikamenten-Konzentrationen im Blut von Patienten (Therapeutisches Drug Monitoring – TDM) die Patientenversorgung bei gleichzeitiger Kostenreduktion verbessern können.

Viele Publikationen belegen die Notwendigkeit einer individuellen Medikamenten-Dosierung bei Kindern und Erwachsenen; wenige, jedoch überzeugende Studien sprechen für die Kosteneffizienz...

Keywords: Bayessche adaptive Kontrollstrategie, Pädiatrie, Pharmakodynamik, Pharmakokinetik, Populationsmodell, therapeutisches Drug Management, therapeutisches Drug Monitoring (TDM), Zielkonzentration, Bayesian adaptive control, Pediatrics, pharmacodynamics, pharmacokinetics, population modeling, target concentration, therapeutic drug management, therapeutic drug monitoring (TDM)