Items for "pharmacodynamic factors"

The influence of sequence variations in factor VII, -glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement

The degree of interpatient variability in the warfarin dose required to achieve the desired anticoagulant response can only partly be explained by polymorphisms in the CYP2C9 gene, suggesting that additional genetic factors such as polymorphisms in genes involved in blood coagulation may influence warfarin dose requirement...

Keywords: Polymorphism, warfarin, cytochrome P450 2C9, pharmacodynamic factors, regression model