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Items for "phage display"

Enzymatic profiling of human kallikrein 14 using phage-display substrate technology

The human KLK14 gene is one of the newly identified serine protease genes belonging to the human kallikrein family, which contains 15 members...

Keywords: extracellular matrix protein, kallikrein, phage display, protease, substrate

03/2005 | Biological Chemistry, Walter de Gruyter

Mapping of B-cell epitopes in E. coli asparaginase II, an enzyme used in leukemia treatment

The enzyme L-asparaginase is a crucial component in the treatment of acute lymphoblastic leukemia (ALL)...

Keywords: acute lymphoblastic leukemia, anti-asparaginase antibodies, epitope mapping, phage display, SPOTs

06/2005 | Biological Chemistry, Walter de Gruyter

Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A

Pregnancy-associated plasma protein-A (PAPP-A) is a metalloprotease that cleaves insulin-like growth factor-binding proteins (IGFBPs) to release bioactive levels of free insulin-like growth factor...

Keywords: antibody engineering, internally quenched protease substrate, phage display

05/2007 | Biological Chemistry, Walter de Gruyter

Selection of vimentin-specific antibodies from the HuCAL^® phage display library by subtractive panning on formalin-fixed, paraffin-embedded tissue

We describe the direct isolation of specific antibodies on formalin-fixed, paraffin-embedded (FFPE) tissue...

Keywords: disease markers, formalin fixation, histology, immunohistochemistry, Monoclonal antibodies, phage display

06/2007 | Biological Chemistry, Walter de Gruyter

Isolation and comparative characterization of Ki-67 equivalent antibodies from the HuCAL^® phage display library

It has been shown that a repetitive motif with the sequence FKEL(F) within the Ki-67 antigen (pKi-67) serves as an epitope for the Ki-67 antibody and equivalent clones...

Keywords: epitope analysis, immunohistochemistry, Ki-67 antigen, Monoclonal antibodies, phage display, tissue fixation

07/2006 | Biological Chemistry, Walter de Gruyter

Development of peptides specifically modulating the activity of KLK2 and KLK3

The prostate produces several proteases, the most abundant ones being kallikrein-related peptidase 3 (KLK3, PSA) and KLK2 (hK2), which are potential targets for tumor imaging and treatment...

Keywords: hK2, kallikrein, peptide modification, phage display, prostate cancer, PSA

06/2008 | Biological Chemistry, Walter de Gruyter

Substrate specificity determination of mouse implantation serine proteinase and human kallikrein-related peptidase 6 by phage display

We constructed a random library of hexapeptides displayed on the surface of bacteriophage T7 to determine the substrate specificity of proteinases...

Keywords: enzyme specificity, human kallikrein-related peptidase, implantation serine proteinase, phage display, T7 bacteriophage

08/2008 | Biological Chemistry, Walter de Gruyter

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