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PET
Items for "PET"
Syntheses of two potential dopamine D4 receptor radioligands: 18F labelled chromeno[3,4-c]pyridin-5-ones
The dopamine D4 receptor is hypothesized to relate with the pathophysiology and pharmacotherapy of schizophrenia while its level in brain regions is much lower and to date no suitable tracer is available for the study of D4 receptor in vivo ...
Keywords: Fluorine-18, Chromeno[3,4-c]pyridin–5-ones, Radio-chemical synthesis, PET, Dopamine D4 receptor
02/2006 | Radiochimica Acta, Oldenbourg WissenschaftsverlagPreparation of [61Cu]pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex as a possible PET radiopharmaceutical
Copper-61 (T1/2=3.33 h) produced via the natZn(p,x) 61Cu nuclear reaction using natural zinc target, was separated from the irradiated target material by a two-step method developed in our laboratory and was used for the preparation of [61Cu]-pyruvaldehyde- bis (N4-methylthiosemicarbazone) ([61Cu]-PTSM) using an in house-made PTSM ligand...
Keywords: Copper-61, PTSM, Radiopharmaceutical, Cyclotron, PET
02/2006 | Radiochimica Acta, Oldenbourg WissenschaftsverlagSimplified, automated synthesis of 3′-[18F]fluoro-3′-deoxy-thymidine ([18F]FLT) and simple method for metabolite analysis in plasma
3′[18F]Fluoro-3′-deoxy-thymidine ([18F]FLT) (III) has been discussed to be a promising tracer for assessing tumor proliferation...
Keywords: [18F]FLT, PET, Tumor proliferation, Anhydrothymidine, Metabolite analysis
08/2006 | Radiochimica Acta, Oldenbourg WissenschaftsverlagPreparation and radiosynthesis of [18F]FE@CFN (2-[18F]fluoroethyl 4-[N-(1-oxopropyl)-N-phenylamino]-1-(2-phenylethyl)-4-piperidinecarboxylate): a potential μ-opioid receptor imaging agent
PET imaging of the μ-opioid receptor (OR) is still restricted to [ 11C]carfentanil ([ 11C]CFN) but its use is limited due to its short half-life and high agonistic potency...
Keywords: Opioid receptor, Carfentanil, Fluorine-18, Fluoroalkylation, PET
01/2007 | Radiochimica Acta, Oldenbourg Wissenschaftsverlag18F-Fluorodeoxyglucose positron emission tomography in restaging of colorectal cancer
AIM, METHOD: Recommendations for the use of FDG-PET in relapsed colorectal cancer and the decision of reimbursement should base on published studies and on their level of evidence...
Keywords: PET, FDG, kolorektales Karzinom, evidenzbasierte Medi-zin, Kosteneffektivität
01/2003 | Nuklearmedizin, SchattauerHigh non-specific binding of the 1 -selective radioligand 2-125I-ICI-H
AIM: As results of cardiac biopsies suggest, myocardial 1 -adrenoceptor density is reduced in patients with chronic heart failure...
Keywords: SPECT, PET β1 -Adrenozeptor Radioliganden, kardiale Bildgebung
01/2003 | Nuklearmedizin, SchattauerRadioligands for imaging myocardial - and -adrenoceptors
Alpha- and beta-adrenoceptors play an important role in the control of heart function. According to their molecular, biological, and pharmacological characteristics, they are subdivided into 1-, 2- and 1-, 2-, 3-, 4-adrenoceptors...
Keywords: Adrenozeptoren, Myokard, PET
01/2003 | Nuklearmedizin, SchattauerHodgkin's lymphoma in nuclear medicine: diagnostic and therapeutic aspects
Today, diagnostic and therapeutic strategies of Hodgkin lymphoma (HL) with positrone emission tomography and radioiummunotherapy include state-of-the-art nuclear medicine which require the cooperation between oncology and nuclear medicine...
Keywords: Hodgkin-Lymphom, PET, Radioimmuntherapie, Multizenterstudie
01/2003 | Nuklearmedizin, SchattauerReimbursement of the PET in oncology in Europe: a questionnaire based survey
AIM: The discussion in Germany about the reimbursement of the 18F-fluorodeoxyglucose Positron-Emissiontomography (FDG-PET) in oncology should make use of the experience from the other European countries. METHOD: A questionnaire was sent to 23 PET-institutions in Europe, outside from Germany, in January 2003...
Keywords: PET, Vergütung, Europa
01/2003 | Nuklearmedizin, Schattauer18F-Deoxyglucose PET for the staging of oesophageal cancer
AIM: Evaluation of the influence of histopathologic sub-types and grading of primaries of oesophageal cancer, relative to their size and location, on the uptake of 18F-deoxyglucose (FDG) as measured by positron emission tomography (PET). METHODS: 50 consecutive patients were evaluated...
Keywords: PET, Ösophaguskarzinom, Grading
01/2003 | Nuklearmedizin, SchattauerPET in neuroscience: Dopaminergic, GABA/benzodiazepine, and opiate system
This article gives an overview on radiotracer imaging with positron emission tomography (PET) in measuring various aspects of neurotransmission...
Keywords: PET, dopaminerges System, GABA/Benzodiazepin-system, Opiatsystem
01/2004 | Nuklearmedizin, SchattauerColorectal cancer patients before resection of hepatic metastases. Impact of 18F-FDG PET on detecting extrahepatic disease
Aim: Evaluation of the role of FDG-PET in comparison to conventional staging methods for detecting extrahepatic tumour deposits prior to resection of liver metastases...
Keywords: PET, FDG, Kolonkarzinom, Lebermetastasen, Lokalrezidiv
01/2004 | Nuklearmedizin, Schattauer18FDG-PET in 733 consecutive patients with or without side-by-side CT evaluation: Analysis of 921 lesions
Side-by-side analysis of CT and conventional 18FDG-PET in oncological imaging is well established. Aim of this study was to find out which patients or diagnostic groups may benefit the most from the newly introduced integrated PET/CT scanners...
Keywords: PET/CT, PET, Side-by-side-Analyse, Bildfusion
01/2004 | Nuklearmedizin, SchattauerAnatomical accuracy of lesion localization. Retrospective interactive rigid image registration between 18F-FDG-PET and X-ray CT
The aim of this study was to evaluate the anatomical accuracy and reproducibility of retrospective interactive rigid image registration (RIR) between routinely archived X-ray computer tomography (CT) and positron emission tomography performed with 18F-deoxyglucose (FDG-PET) in oncological patients...
Keywords: PET, CT, Bildregistrierung, Bildfusion, FDG
01/2005 | Nuklearmedizin, SchattauerThe influence of filtered back-projection and iterative reconstruction on partial volume correction in PET
Aim: We assess the influence of the reconstruction algorithms [OS-EM for the iterative one vs. a filtered back-projection in Fourier space (DiFT)] on partial volume correction in PET employing a fully 3D 3-compartment MR based PV-correction algorithm...
Keywords: Positronenemissionstomographie, Kernspintomographie, dreidimensionale Partialvolumen-Korrektur, Rekonstruktion, gefilterte Rückprojektion, OSEM, Phantommessungen
01/2005 | Nuklearmedizin, SchattauerCardiac resynchronisation therapy: Effects on myocardial perfusion at rest, after vasodilation and oxygen consumption
Aim: Cardiac resynchronisation therapy (CRT) has been shown to improve haemodynamics and clinical symptoms in heart failure patients...
Keywords: Herzinsuffizienz, Linksschenkelblock, Perfusion, Sauerstoffverbrauch, PET
01/2006 | Nuklearmedizin, SchattauerHigh energy probe for detecting lymph node metastases with 18F-FDG in patients with head and neck cancer
AIM: of this study was to validate a newly developed high energy probe (positron emission probe, PEP) optimised for localising PET tracers in vivo...
Keywords: Hochenergiesonde, 18F-FDG, PET, Kopf-Hals-Tumore
01/2006 | Nuklearmedizin, SchattauerAttenuation correction for myocardial perfusion imaging. A comparison between SPECT and PET imaging by polar map analysis
AIM: We investigated the impact of photon attenuation in myocardial perfusion imaging with SPECT and PET in patients with coronary artery disease...
Keywords: Myokardperfusion, SPECT, PET, Schwächungskorrektur, Polar- Map-Analyse
01/2006 | Nuklearmedizin, SchattauerPET with 18 F-DOPA in the imaging of parathyroid adenoma in patients with primary hyperparathyroidism. A pilot study
Preoperative localization of parathyroid adenomas (PA) can shorten operation time and improve curative rate; it becomes especially important in minimally invasive surgical techniques...
Keywords: PET, MIBI-Szintigraphie, 18F-DOPA, Primärer Hyperparathyreoidismus, Ultraschall
01/2006 | Nuklearmedizin, SchattauerGender dependent rate of metabolism of the opioid receptor-PET ligand [ 18 F]fluoroethyldiprenorphine
AIM: The morphinane-derivate 6-O-(2-[ 18 F]fluoroethyl)-6-O-desmethyldiprenorphine ([ 18 F]FDPN) is a nonselective opioid receptor ligand currently used in positron emission tomography (PET)...
Keywords: Fluor-18, Diprenorphin, PET, Metabolismus, geschlechtsspezifische Unterschiede, Modeling
01/2006 | Nuklearmedizin, SchattauerImproved non-invasive T-Staging in non-small cell lung cancer by integrated 18F-FDG PET/CT
AIM: In this prospective study, reliability of integrated 18F-FDG PET/CT for staging of NSCLC was evaluated and compared to MDCT or PET alone...
Keywords: NSCLC, PET/CT, PET, MDCT, T-staging
01/2007 | Nuklearmedizin, SchattauerRadiosynthesis of the adenosine A3 receptor ligand 5-(2-[18F]fluoroethyl) 2,4-diethyl-3-(ethylsulfanylcarbonyl)- 6-phenylpyridine-5-carboxylate ([18F]FE@SUPPY)
Since to date very limited information on the distribution and function of the adenosine A3 receptor is available, the development of a suitable radioligand is needed...
Keywords: Adenosine, PET, Receptor, Fluorine-18, radioligand
02/2008 | Radiochimica Acta, Oldenbourg Wissenschaftsverlag