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Items for "paraoxonase"

Paraoxonase and platelet-activating factor acetylhydrolase activities in lipoproteins of ?-thalassemia/hemoglobin E patients

Background: Iron-induced oxidative stress may be implicated in the alteration of the lipoprotein-associated antioxidant enzymes paraoxonase 1 (PON1) and platelet-activating factor acetylhydrolase (PAF-AH), leading to atherosclerosis-related vascular complication in patients with ?-thalassemia hemoglobin E (?-thal/Hb E).

Methods: Plasma and lipoprotein enzyme activities of PON1 and PAF-AH were studied in 13 mild to moderate and 15 severe cases of ?-thal/Hb E in comparison with 15 normal subjects.

Results: PON1 activity was significantly reduced in association with oxidative stress in the patients...

Keywords: lipoprotein, oxidative stress, paraoxonase, platelet-activating factor acetylhydrolase, ?-thalassemia

07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians

Background: Paraoxonases (PON) are members of an enzyme family involved in preventing low-density lipoprotein oxidation and therefore protecting against atherosclerotic plaque formation.

Methods: We studied the Met55Leu and Gln192Arg PON1 polymorphisms in 712 patients (437 Caucasian- and 275 African-Brazilians) who underwent coronary angiography.

Results: Among Caucasian-Brazilians, the homozygous 55LeuLeu frequency was higher among patients with significant coronary artery disease (CAD, obstructive lesions ?50%) than among lesion-free controls (51% vs...

Keywords: African-Brazilians, coronary artery disease, paraoxonase, Polymorphism

07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Serum homocysteine levels and paraoxonase 1 activity in preschool aged children in Greece

Background: Over the past decade, it has been well established that elevated total serum homocysteine (tHcy) in adults is associated with increased risk of cardiovascular and thromboembolic diseases...

Keywords: age, cardiovascular disease, children, homocysteine, paraoxonase, sex

05/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Lipid peroxidation and homocysteine levels in Behçet's disease

Background: The aim of this study was to investigate serum paraoxonase (PON1) activity in relation to homocysteine, malondialdehyde (MDA) and lipid parameters in active and inactive Behçet's disease (BD).

Methods: A total of 46 consecutive BD patients and 25 healthy control subjects were included in the present study.

Results: Serum PON1 activity in both active and inactive BD was significantly lower compared with healthy subjects (p<0.05)...

Keywords: homocysteine, lipid peroxidation, paraoxonase

09/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Lipid peroxidation in stroke patients

Background: Paraoxonase is high-density lipoprotein (HDL)-associated esterase/lactonase implicated to play a role in the antioxidant and anti-inflammatory properties exerted by HDL...

Keywords: antioxidants, lipid peroxidation, lipoproteins, paraoxonase, Stroke

01/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter