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PAI-1
Items for "PAI-1"
Polymorphism A36G of the tumor necrosis factor receptor 1 gene is associated with PAI-1 levels in obese women
The tumor necrosis factor (TNF) pathway may be implicated in etiopathogenesis of PAI-1 overexpression during obesity...
Keywords: obesity, metabolic syndrome, inflammation, TNFR1, PAI-1
01/2007 | Thrombosis and Haemostasis, SchattauerTiplaxtinin impairs nutritionally induced obesity in mice
To investigate the effect of tiplaxtinin, designed as a synthetic inhibitor of plasminogen activator inhibitor-1 (PAI-1), on obesity, male C57Bl/6 mice (13-14 weeks old) were kept on a high-fat diet (20.1 kJ/g) for four weeks without or with addition of tiplaxtinin (PAI-039) at a dose of 2 mg/g food...
Keywords: PAI-1, obesity, adipose tissue, glucose tolerance, insulin sensitivity
12/2006 | Thrombosis and Haemostasis, SchattauerDisease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma
In epithelial ovarian cancer, the high mortality rate is usually ascribed to late diagnosis, since these tumors commonly lack early-warning symptoms, but tumor-associated biomarkers useful for prognosis or therapy response prediction are in short supply...
Keywords: ovarian cancer, PAI-1, plasminogen activator, plasminogen activator inhibitor type-1, proteolytic factors, tissue kallikreins, uPA, urokinase
08/2006 | Biological Chemistry, Walter de Gruyter