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oxidative stress
Items for "oxidative stress"
Oxidative stress and endothelial dysfunction
This review focuses on the role of vascular oxidative stress in the development and progression of endothelial dysfunction...
Keywords: Endotheliale Dysfunktion, Lipoproteine, oxidativer Stress, Stickstoffmonoxid
01/2007 | Hämostaseologie, SchattauerCoagulation and endothelial dysfunction during longterm hyperdynamic porcine bacteremia effects of selective inducible nitric oxide synthase inhibition
Coagulation abnormalities have been implicated in the pathogenesis of sepsis and organ dysfunction. Nitric oxide (NO) is regarded as a critical mediator of many vascular pathologies, including sepsis...
Keywords: Coagulation, DIC, nitric oxide, oxidative stress, sepsis
00/0000 | Thrombosis and Haemostasis, SchattauerPhosphoinositide 3-kinase signaling in the cellular response to oxidative stress
Oxidative stress is linked to the pathogenesis and pathobiochemistry of various diseases, including cancer, diabetes and cardiovascular disorders...
Keywords: AKT, FoxO-proteins, oxidant signaling, oxidative stress, phosphoinositide 3?-kinase (PI 3-kinase), protein kinase B, signal transduction
03/2005 | Biological Chemistry, Walter de GruyterDoxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells
Exposure of rat liver epithelial cells to doxorubicin, an anthraquinone derivative widely employed in cancer chemotherapy, led to a dose-dependent decrease in gap junctional intercellular communication (GJC)...
Keywords: connexin-43, extracellular signal-regulated kinase (ERK), gap junction, mitogen-activated protein (MAP) kinase, oxidative stress, signal transduction, stress signaling
03/2005 | Biological Chemistry, Walter de GruyterHydrogen peroxide causes greater oxidation in cellular RNA than in DNA
Human A549 lung epithelial cells were challenged with 18O-labeled hydrogen peroxide ([18O]-H2O2), the total RNA and DNA extracted in parallel, and analyzed for 18O-labeled 8-oxo-7,8-dihydroguanosine ([18O]-8-oxoGuo) and 8-oxo-7,8-dihydro-2?-deoxyguanosine ([18O]-8-oxodGuo) respectively, using high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-MS/MS)...
Keywords: A549 cells, electrospray ionization, Mass spectrometry, oxidative stress, 8-oxodGuo, 8-oxoGuo
04/2005 | Biological Chemistry, Walter de GruyterA method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration
We developed a novel method for the simultaneous extraction and analysis of total tissue RNA and DNA to quantify the RNA and DNA oxidation products 8-oxo-7,8-dihydroguanosine and 8-oxo-7,8-dihydro-2?-deoxyguanosine using HPLC coupled to electrochemical detection (HPLC-ECD)...
Keywords: doxorubicin, free radical, nucleic acids, oxidative stress, 8-oxodGuo, 8-oxoGuo
01/2006 | Biological Chemistry, Walter de GruyterProtein oxidation and proteolysis
One of the hallmarks of chronic or severe oxidative stress is the accumulation of oxidized proteins, which tend to form high-molecular-weight aggregates...
Keywords: oxidative stress, PARP, proteasome, protein oxidation, ubiquitination
10/2006 | Biological Chemistry, Walter de GruyterAspects of the biological redox chemistry of cysteine: from simple redox responses to sophisticated signalling pathways
The last decade has witnessed an increased interest in cysteine modifications such as sulfenic and sulfinic acids, thiyl radicals, sulfenyl-amides and thiosulfinates, which come together to enable redox sensing, activation, catalysis, switching and cellular signalling...
Keywords: oxidative stress, peroxiredoxin, sulfenic acid, sulfenyl amide, sulfinic acid, thiosulfinate
10/2006 | Biological Chemistry, Walter de GruyterSinglet oxygen inactivates protein tyrosine phosphatase-1B by oxidation of the active site cysteine
Singlet oxygen (1O2), an electronically excited form of molecular oxygen, is a mediator of biological effects of ultraviolet A radiation, stimulating signaling cascades in human cells...
Keywords: oxidative stress, photosensitization, signal transduction, tyrosine phosphorylation, ultraviolet radiation
10/2006 | Biological Chemistry, Walter de GruyterAir pollution-associated fly ash particles induce fibrotic mechanisms in primary fibroblasts
Air pollution is associated with a variety of respiratory and cardiovascular disorders, including fibrosis...
Keywords: advanced glycation endproducts, extracellular matrix, fibrosis, oxidative stress, particulate matter
10/2006 | Biological Chemistry, Walter de GruyterJanus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal
Endothelial NO synthase (eNOS) is the predominant enzyme responsible for vascular NO synthesis...
Keywords: l-arginine, asymmetric dimethyl-l-arginine, NADPH oxidase, oxidative stress, (6R)-5,6,7,8-tetrahydrobiopterin
12/2006 | Biological Chemistry, Walter de GruyterWhich endothelium-derived factors are really important in humans?
The endothelium plays a primary role in the local control of vascular function and structure, mainly by the production and release of NO, a potent vasodilator that also inhibits all the mechanisms involved in the pathogenesis of atherosclerosis, thus protecting the vessel wall against the development of atherosclerosis and thrombosis...
Keywords: circulation, endothelium, nitric oxide, oxidative stress, vascular reactivity
02/2006 | Biological Chemistry, Walter de GruyterDoes Helicobacter pylori cause gastric cancer via oxidative stress?
Epidemiologic evidence strongly supports a causal role for
Keywords: antioxidants, gastritis, Helicobacter pylori, oxidative stress
04/2006 | Biological Chemistry, Walter de GruyterThe tissue kallikrein-kinin system protects against cardiovascular and renal diseases and ischemic stroke independently of blood pressure reduction
Tissue kallikrein (hK1) cleaves low-molecular-weight kininogen to produce kinin peptide, which binds to kinin receptors and triggers a wide spectrum of biological effects...
Keywords: Angiogenesis, Apoptosis, brain, heart, hypertension, kinin B2 receptor, oxidative stress, tissue kallikrein
06/2006 | Biological Chemistry, Walter de GruyterBinding of aflatoxins to the 20S proteasome: effects on enzyme functionality and implications for oxidative stress and apoptosis
Aflatoxins (AF) are contaminants of improperly stored foods; they are potent genotoxic and carcinogenic compounds, exerting their effects through damage to DNA...
Keywords: aflatoxin, Apoptosis, HepG2, oxidative stress, proteasome, proteolytic activity
01/2007 | Biological Chemistry, Walter de GruyterHydrophobic bile salts trigger ceramide formation through endosomal acidification
Hydrophobic bile salts activate NADPH oxidase through a ceramide- and PKC?-dependent pathway as an important upstream event of bile salt-induced hepatocyte apoptosis...
Keywords: bile acids, CD95, chloride, FAS, oxidative stress, p47phox, sphingomyelinase
02/2007 | Biological Chemistry, Walter de GruyterInverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders
Keywords: cardiac disorders, immune activation, neopterin, oxidative stress, selenium, tryptophan degradation
09/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterReliability of oxidative stress biomarkers in hemodialysis patients: a comparative study
Keywords: antioxidants, chronic kidney failure, lipid peroxides, malondialdehyde, oxidative stress, renal dialysis, vitamins
09/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterParaoxonase and platelet-activating factor acetylhydrolase activities in lipoproteins of ?-thalassemia/hemoglobin E patients
Keywords: lipoprotein, oxidative stress, paraoxonase, platelet-activating factor acetylhydrolase, ?-thalassemia
07/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterMetabolic changes, hypothalamo-pituitary-adrenal axis and oxidative stress after short-term starvation in healthy pregnant women
Keywords: Fetal programming, isoprostanes, malondialdehyde, oxidative stress, pregnancy
03/2007 | Journal of Perinatal Medicine, Walter de GruyterIncinerator fly ash provokes alteration of redox equilibrium and liberation of arachidonic acid in vitro
Numerous epidemiological studies have associated exposure to ambient particulate matter (PM) with pulmonary and cardiovascular health effects...
Keywords: cyclooxygenase-2, incinerator fly ash, macrophages, oxidative stress, particulate matter, reactive oxygen species
10/2006 | Biological Chemistry, Walter de GruyterMolecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function
Selenoproteins have been recognized as modulators of brain function and signaling...
Keywords: Apoptosis, embryogenesis, excitotoxicity, glial cells, oxidative stress, phosphoinositides, selenium
10/2007 | Biological Chemistry, Walter de GruyterPreventing in vitro lipoperoxidation in the malondialdehyde-thiobarbituric assay
The malondialdehyde-thiobarbituric acid assay is widely used to study lipid peroxidation...
Keywords: butylated hydroxytoluene (BHT), high pressure liquid chromatography (HPLC), lipid peroxidation, malondialdehyde, oxidative stress
08/2004 | Clinical Chemical Laboratory Medicine, Walter de GruyterOxidative stress: potential of distinct peroxide determination systems
When reactive oxygen species attack biological structures, peroxides, which are short-lived oxidative intermediates, are generated...
Keywords: antioxidants, lipid peroxidation, oxidative stress, oxidative stress measurement, ox-LDL antibodies, peroxides
08/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter?-Tocopherol as an antiretroviral therapy supplement for HIV-1-infected patients for increased lymphocyte viability
The aim of our study was to evaluate the benefits of supplementation with 800 mg/day of ?-tocopherol with regard to cellular viability in HIV-1 seropositive patients undergoing anti-retroviral therapy...
Keywords: antiretroviral therapy, Apoptosis, cellular viability, HIV, oxidative stress, ?-tocpherol
04/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter“Coelionomics”: towards understanding the molecular pathology of coeliac disease
Coeliac disease (CD) is an inflammatory disorder of the small intestine characterised by a permanent intolerance to gluten-derived peptides...
Keywords: Apoptosis, coeliac disease, matrix metalloproteinases, oxidative stress, proliferation and differentiation
07/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterAdvanced oxidation protein products in serum of patients with myotonic disease type I: association with serum ?-glutamyltransferase and disease severity
Steinert's disease (myotonic dystrophy type 1; MD) is caused by a CTG trinucleotide expansion on 19q13.3...
Keywords: ?-glutamyltransferase, myotonic dystrophy, oxidative stress
07/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterAlteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency
Hyperhomocysteinemia is a risk factor in obstetrical complications such as pre-eclampsia, ‘hemolysis, elevated liver enzymes, low platelet’ (HELLP)-syndrome and placental insufficiency...
Keywords: cystathionine, hemolysis, elevated liver enzymes, low platelet (HELLP) syndrome, homocysteine, oxidative stress, pre-eclampsia
10/2004 | Clinical Chemical Laboratory Medicine, Walter de GruyterHomocysteine and vascular disease in diabetes: a double hit?
Cardiovascular disease is a major problem in diabetes, and risk factors presumably unrelated to diabetes, such as hyperhomocysteinaemia, may be related to the development of cardiovascular complications in diabetic individuals...
Keywords: cardiovascular disease, diabetes, endothelial function, homocysteine, oxidative stress
10/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterSimple PCR heteroduplex, SSCP mutation screening methods for the detection of novel catalase mutations in Hungarian patients with type 2 diabetes mellitus
Background: The enzyme catalase is the main regulator of hydrogen peroxide metabolism...
Keywords: catalase gene, diabetes, nucleotide sequence, oxidative stress, PCR heteroduplex, PCR-SSCP
12/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterPlasma homocysteine and markers for oxidative stress and inflammation in patients with coronary artery disease – a prospective randomized study of vitamin supplementation
Background: Elevated plasma levels of total homocysteine (tHcy) are associated with an increased risk of developing occlusive vascular diseases...
Keywords: cardiovascular disease, F 2-isoprostanes, homocysteine, lipid peroxidation, oxidative stress
06/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterAutomation and validation of a fast method for the assessment of in vivo oxidative stress levels
Keywords: age, automated procedure, gender, manual method, oxidative stress
11/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterMarkers of oxidative stress in children with Down syndrome
Keywords: antioxidants, carbonyls, Down syndrome, 4-hydroxy-2-nonenal, oxidative stress
03/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterIncreased free malondialdehyde concentrations in smokers normalise with a mixed fruit and vegetable juice concentrate: a pilot study
Keywords: homocysteine, malondialdehyde, oxidative stress, phytonutrients, smoking
04/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterInfluence of human haptoglobin polymorphism on oxidative stress induced by free hemoglobin on red blood cells
Keywords: haptoglobin phenotypes, hemoglobin, hemolysis, oxidative stress, red blood cell membranes
05/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterThe reduction of cholesteryl linoleate in lipoproteins: an index of clinical severity in ?-thalassemia/Hb E
Keywords: cholesteryl linoleate, hypocholesterolemia, non-transferrin bound iron, oxidative stress, thalassemia
05/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterA long and winding road: defining the biological role and clinical importance of paraoxonases
Paraoxonase-1 (PON1) is an enzyme belonging to a three-member gene family, each of which is highly conserved in mammalian evolution...
Keywords: high-density lipoproteins, innate immunity, lactonase, oxidative stress, quorum quenching, toxicology, vascular disease
09/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterLipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21
Keywords: Down syndrome, free radicals, lipid peroxidation, malondialdehyde, oxidative stress
01/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterOxidative stress evaluated using an automated method for hydroperoxide estimation in patients with coronary artery disease
Keywords: atherosclerosis, coronary artery disease, diabetes, hydroperoxides, oxidative stress, risk factors
03/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterMethionine metabolism in an animal model of sepsis
Keywords: S-adenosylmethionine, DNA methylation, homocysteine metabolism, glutathione, oxidative stress, sepsis, transmethylation
10/2008 | Clinical Chemical Laboratory Medicine, Walter de GruyterHypochlorous acid is a potent inactivator of human plasminogen at concentrations secreted by activated granulocytes
Keywords: atherosclerosis, Coagulation, myeloperoxidase, oxidative stress, Plasmin, thiols, thrombosis
10/2008 | Clinical Chemical Laboratory Medicine, Walter de GruyterCoenzyme Q10 and high-sensitivity C-reactive protein in ischemic and idiopathic dilated cardiomyopathy
Keywords: antioxidants, Cardiomyopathy, coenzyme Q10, C-reactive protein, Heart failure, oxidative stress
03/2008 | Clinical Chemical Laboratory Medicine, Walter de GruyterCarbonylation of platelet proteins occurs as consequence of oxidative stress and thrombin activation, and is stimulated by ageing and type 2 diabetes
Keywords: ageing, oxidative stress, thrombin, type 2 diabetes
04/2008 | Clinical Chemical Laboratory Medicine, Walter de GruyterGlutathione S-transferase variants increase susceptibility for late-onset Alzheimer's disease: association study and relationship with apolipoprotein E ?4 allele
Keywords: apolipoprotein E, glutathione S-transferase, oxidative stress, polymorphisms
04/2008 | Clinical Chemical Laboratory Medicine, Walter de GruyterEvaluation of oxidative stress and inflammation in obese adults with metabolic syndrome
Keywords: inflammation, metabolic syndrome, oxidative stress
04/2008 | Clinical Chemical Laboratory Medicine, Walter de GruyterModulation of longevity-associated genes by estrogens or phytoestrogens
Females live longer than males. We have shown that the higher levels of estrogens in females protect them against aging, by up-regulating the expression of antioxidant, longevity-related genes, such as that of selenium-dependent glutathione peroxidase (GPx) and Mn-superoxide dismutase (Mn-SOD)...
Keywords: aging, antioxidant enzymes, estrogenic compounds, free radicals, gender, oxidative stress
03/2008 | Biological Chemistry, Walter de GruyterFoxO transcription factors in oxidative stress response and ageing – a new fork on the way to longevity?
Forkhead box O (FoxO) transcription factors are important downstream targets of the PI3K/Akt signaling pathway and crucial regulators of cell fate...
Keywords: ageing, Angiogenesis, atherosclerosis, endothelial cell, FoxO, longevity, oxidative stress, smooth muscle cell
03/2008 | Biological Chemistry, Walter de GruyterSirt1 protects the heart from aging and stress
The prevalence of heart diseases, such as coronary artery disease and congestive heart failure, increases with age...
Keywords: Apoptosis, hormesis, longevity factor, oxidative stress, sirtuin, stress resistance
03/2008 | Biological Chemistry, Walter de GruyterPotential biomarkers of ageing
Life span in individual humans is very heterogeneous. Thus, the ageing rate, measured as the decline of functional capacity and stress resistance, is different in every individual...
Keywords: ageing, hormones, inflammation, oxidative stress, protein glycation
03/2008 | Biological Chemistry, Walter de GruyterRegulation of proteasome-mediated protein degradation during oxidative stress and aging
Protein degradation is a physiological process required to maintain cellular functions...
Keywords: aging, oxidative stress, proteasome, protein degradation, protein oxidation
03/2008 | Biological Chemistry, Walter de GruyterAllantoin as a marker of oxidative stress in human erythrocytes
Keywords: allantoin, antioxidants, human erythrocytes, oxidative stress, uric acid
09/2008 | Clinical Chemical Laboratory Medicine, Walter de GruyterThe effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status
Keywords: antioxidant status, Hyperthyroidism, hypothyroidism, oxidative stress
07/2008 | Clinical Chemical Laboratory Medicine, Walter de GruyterPost-delivery oxidative stress in women with preeclampsia or IUGR
Keywords: gestational hypertension, isoprostanes, IUGR, malondialdehyde, oxidative stress, PE, pregnancy
07/2008 | Journal of Perinatal Medicine, Walter de GruyterIncreased levels of 8-hydroxydeoxyguanosine and its relationship with lipid peroxidation and antioxidant vitamins in lung cancer
Keywords: antioxidants, DNA damage, 8-hydroxy-2?-deoxuguanosine, Lung Cancer, malondialdehyde, oxidative stress
01/2008 | Clinical Chemical Laboratory Medicine, Walter de GruyterAntioxidant defense capacity in scleroderma patients
Keywords: antioxidant defense, oxidative stress, scleroderma, superoxide dismutase (SOD), systemic sclerosis
06/2008 | Clinical Chemical Laboratory Medicine, Walter de GruyterOxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome
Keywords: carbonyl protein, C-reactive protein, heat shock protein 70, metabolic syndrome, oxidative stress
06/2008 | Clinical Chemical Laboratory Medicine, Walter de GruyterHigh free serum acrolein levels in bacterial infection and other disease states associated with oxidative stress: a potential biomarker?
No available
Keywords: cerebrovascular accident, cirrhosis, diabetes, myeloperoxidase, oxidative stress, pneumonia, uremia
11/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterDecreased plasmalogen concentration as a surrogate marker of oxidative stress in patients presenting with acute coronary syndromes or supraventricular tachycardias
No available
Keywords: Acute coronary syndrome, coronary angioplasty, oxidative stress, plasmalogens, radio-frequency catheter ablation, supraventricular tachycardia
05/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter