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Items for "ovarian cancer"

Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins

Human kallikrein 4 (hK4) is a member of the expanded family of human kallikreins, a group of 15 secreted proteases...

Keywords: cancer metastasis, extracellular matrix, human kallikrein 4, ovarian cancer, prognostic markers, prostate cancer, serine protease, serine protease inhibitors

06/2006 | Biological Chemistry, Walter de Gruyter

Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells

The human tissue kallikrein family of serine proteases (hK1–hK15 encoded by the genes KLK1–KLK15) is involved in several cancer-related processes...

Keywords: nude mice, ovarian cancer, serine protease, tumor invasion

06/2006 | Biological Chemistry, Walter de Gruyter

Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma

In epithelial ovarian cancer, the high mortality rate is usually ascribed to late diagnosis, since these tumors commonly lack early-warning symptoms, but tumor-associated biomarkers useful for prognosis or therapy response prediction are in short supply...

Keywords: ovarian cancer, PAI-1, plasminogen activator, plasminogen activator inhibitor type-1, proteolytic factors, tissue kallikreins, uPA, urokinase

08/2006 | Biological Chemistry, Walter de Gruyter

Protein profiling as a diagnostic tool in clinical chemistry: a review

Serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) appears to be an important diagnostic tool for a whole range of diseases...

Keywords: biomarker, decision tree, diagnostic value, ovarian cancer, post-analytical conditions, pre-analytical conditions, prostate cancer, protein profiling, proteomics, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

12/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Technical evaluation of the Beckman Coulter OV-Monitor (CA 125 antigen) immunoassay

Background: The CA 125 antigen is a large (200–1000 kDa) glycoprotein, present within normal and benign ovarian tissue...

Keywords: Abbott AxSYM, Bayer ADVIA Centaur, CA 125, immunoassay, ovarian cancer, tumor marker, UniCel? DxI 800

04/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Alternative antibody for the detection of CA125 antigen: a European multicenter study for the evaluation of the analytical and clinical performance of the Access^® OV Monitor assay on the UniCel^® DxI 800 Immunoassay System

Background: Cancer antigen CA125 is known as a valuable marker for the management of ovarian cancer.

Methods: The analytical and clinical performance of the Access OV Monitor Immunoassay System (Beckman Coulter) was evaluated at five different European sites and compared with a reference system, defined as CA125 on the Elecsys System (Roche Diagnostics).

Results: Total imprecision (%CV) of the OV Monitor ranged between 3.1% and 8.8%, and inter-laboratory reproducibility between 4.7% and 5.0%...

Keywords: CA125, diagnosis, method comparison, ovarian cancer

05/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

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