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Items for "Nrf2"

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

Cells are equipped with a number of transcriptional factors that safeguard against various environmental insults...

Keywords: CUL3-BTB E3 ligase, DLG motif, ETGE motif, Keap1, Nrf2, oxidative stress sensor

10/2006 | Biological Chemistry, Walter de Gruyter
Glutathione peroxidases and redox-regulated transcription factors

Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system...

Keywords: Cancer, glutathione peroxidases, inflammation, NF-?B, Nrf2

10/2006 | Biological Chemistry, Walter de Gruyter