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Items for "normalization"

Comparison of Preprocessing Procedures for Oligo-nucleotide Micro-arrays by Parametric Bootstrap Simulation of Spike-in Experiments

OBJECTIVE: Due to scarcity of calibration data for microarray experiments, simulation methods are employed to assess preprocessing procedures...

Keywords: Gene expression profiling, oligo-nucleotide array, normalization

01/2004 | Methods of Information in Medicine, Schattauer
Normalization for Affymetrix GeneChips

OBJECTIVES: The high density oligonucleotide microarrays from Affymetrix (Affymetrix GeneChips) are very popular in biomedical research...

Keywords: Affymetrix, microarray, normalization, data preprocessing

01/2005 | Methods of Information in Medicine, Schattauer
Normalization for Two-channel Microarray Data

OBJECTIVES: In two-channel microarray experiments the measured gene expression levels are affected by many sources of systematic variation...

Keywords: cDNA microarrays, two-color microarrays, normalization, loess regression, data preprocessing

01/2005 | Methods of Information in Medicine, Schattauer
Design and Analysis of Two-color Microarray Experiments Using Linear Models

OBJECTIVES: A variety of linear models have recently been proposed for the design and analysis of microarray experiments...

Keywords: ANOVA techniques, hypothesis testing, normalization, experimental design

01/2005 | Methods of Information in Medicine, Schattauer
How useful are housekeeping genes? Variable expression in melanoma metastases

Background: There is a certain difference in opinion regarding the optimal choice of housekeeping genes used as normalization factors in gene expression analysis...

Keywords: ?-glucuronidase, ?2-microglobulin, endogenous control, hypoxanthine phosphoribosyl transferase, normalization, quantitative reverse transcription PCR

11/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter