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Items for "neurodegeneration"

Functional genomics identifies novel and diverse molecular targets of nutrients in vivo

Genomic responses to nutrients are important determinants of physiological and pathological functions of living systems...

Keywords: antioxidants, ataxia, neurodegeneration, oligodendrocyte, polyphenols, retinoic acid related orphan receptor, tocopherol transfer protein, transcription regulatory networks

08/2004 | Biological Chemistry, Walter de Gruyter

Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice

Cathepsin B (CTSB) and cathepsin L (CTSL) are two widely expressed cysteine proteases thought to predominantly reside within lysosomes...

Keywords: cathepsin, neurodegeneration, Purkinje cell

07/2006 | Biological Chemistry, Walter de Gruyter

Electrophoretic separations of cerebrospinal fluid proteins in clinical investigations

The cerebrospinal fluid (CSF) is a key sample in the research for novel molecular biomarkers of neurodegenerative disorders...

Keywords: cerebrospinal fluid, 2-D electrophoresis, dementia, proteomics, matrix assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF-MS), neurodegeneration

04/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases

Hyperhomocysteinemia (HHcy) is related to central nervous system diseases. Epidemiological studies show a positive, dose-dependent relationship between plasma total homocysteine (tHcy) concentration and neurodegenerative disease risk...

Keywords: brain atrophy, depression, epilepsy, homocysteine, neurodegeneration, vitamin B group