Items for "mustard"

Effect of nitrogen mustard, a vesicant agent, on lymphocyte energy metabolism

Background: The vesicant agents sulfur and nitrogen mustards, which contain chloroethyl groups, are potent inhibitors of DNA synthesis and cell growth, likely changing the utilization of anaerobic glycolysis for energy generation.

Methods: To investigate the effect of nitrogen mustard on cellular energy metabolism, lymphocytes treated with increasing doses of mechlorethamine (HN2), a nitrogen mustard and an analogue of sulfur mustard, were incubated with radiolabeled glucose...

Keywords: energy metabolism, glycogen degradation, glycolysis, mechlorethamine, mustard