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Items for "methylglyoxal"

Interaction of N(carboxymethyl)lysine- and methylglyoxal-modified albumin with endothelial cells and macrophages. Splice variants of RAGE may limit the responsiveness of human endothelial cells to AGEs

In diabetes mellitus an increased risk exists for vascular complications. A role for advanced glycation endproducts (AGEs) in the acceleration of vascular disease has been suggested...

Keywords: Carboxymethyllysine, methylglyoxal, HUVECs, endothelial activation, adhesion molecules, human microvascular endothelial cells

00/0000 | Thrombosis and Haemostasis, Schattauer
Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts

The glyoxalase system consisting of glyoxalase I (GloI) and glyoxalase II (GloII) constitutes a glutathione-dependent intracellular pathway converting toxic 2-oxoaldehydes, such as methylglyoxal, to the corresponding 2-hydroxyacids...

Keywords: drug development, enzyme inhibition, glutathione derivatives, methylglyoxal, molecular modeling

01/2005 | Biological Chemistry, Walter de Gruyter