Items for "methylation"

A novel application of melting curves: utility of peak area calculation for relative methylation quantification

Background: DNA methylation markers appear to be useful in cancer detection, in evaluating the prognosis associated with disease progression, and in detecting the metastatic potential of tumors.

Methods: We present an approach for relative quantification of methylated gene sequences...

Keywords: leukemia, melting curve, methylation, methylation index, peak area calculation