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Items for "meta-analysis"

No interaction between factor V Leiden and hyperhomocysteinemia or MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only study

Homocysteine may have a thrombogenic effect through inhibition of inactivation of factor Va by activated protein C...

Keywords: MTHFR, methylenetetrahydrofolatereductase, homocysteine, factor V Leiden, meta-analysis, case-only, case-control, VITRO

01/2007 | Thrombosis and Haemostasis, Schattauer

Some Problems with the Investigation of Noninferiority in Meta-analysis

OBJECTIVES: Noninferiority trials have become commonplace in recent years. Like individual clinical trials, meta-analyses can also investigate noninferiority...

Keywords: meta-analysis, equivalence, choice of delta, population sets

01/2004 | Methods of Information in Medicine, Schattauer

Meta-Analysis. A Unifying Meta-Likelihood Approach Framing Unobserved Heterogeneity, Study Covariates, Publication Bias, and Study Quality

OBJECTIVES: This contribution provides a unifying concept for meta-analysis integrating the handling of unobserved heterogeneity, study covariates, publication bias and study quality...

Keywords: Evidence-based Medicine, C.A.MAN, meta-analysis, meta-regression, meta-likelihood, nonparametric maximum meta-likelihood, publication bias, unobserved heterogeneity

01/2005 | Methods of Information in Medicine, Schattauer

Thrombophilic risk factors and homocysteine levels in Behets disease in eastern Spain and their association with thrombotic events

Behets disease (BD) is a chronic inflammatory disorder in which thrombosis occurs in about 30% of patients...

Keywords: Behçet’s disease, hyperhomocysteinaemia, thrombophilic risk factors, thrombosis, meta-analysis

04/2006 | Thrombosis and Haemostasis, Schattauer

Factor XIII Val34Leu variant protects against coronary artery disease. A meta-analysis

Several studies suggested that Val34Leu variant of factor XIII (FXIII) might have a protective effect against coronary artery disease (CAD), but studies not supporting these findings have also been published...

Keywords: Coronary disease, factor XIII, Polymorphism, meta-analysis

03/2007 | Thrombosis and Haemostasis, Schattauer

Factor XIII Val34Leu variant and the risk of myocardial infarction. A meta-analysis

Genetic factors are thought to contribute to the pathogenesis of acute myocardial infarction (AMI). A common variant of factor XIII (FXIII), FXIII Val34Leu, may be protective against developing an AMI, but various studies show conflicting results...

Keywords: factor XIII, genetic, meta-analysis, myocardial infarction, risk factor

04/2007 | Thrombosis and Haemostasis, Schattauer

Geographic and host distribution of lignicolous mangrove microfungi

We examined factors that contribute to the structuring of lignicolous mangrove microfungal communities across ocean basins and plant families...

Keywords: biogeography, host specificity, mangroves, marine fungi, meta-analysis

12/2004 | Botanica Marina, Walter de Gruyter

Homocysteine-lowering trials for prevention of vascular disease: protocol for a collaborative meta-analysis

Background: Elevated plasma total homocysteine is a risk factor for cardiovascular disease (CVD), but the randomized trials of dietary supplementation with B-vitamins to lower homocysteine have not yet provided clear evidence of benefit on vascular risk.

Methods: Cumulative meta-analysis of all randomized trials assessing the effects of lowering homocysteine levels with B-vitamins on risk of CVD.

Results: An individual patient data meta-analysis of all randomized trials of the effects on vascular risk of lowering homocysteine with B-vitamins will maximize the power to assess the epidemiologically predicted differences in risk...

Keywords: folic acid, homocysteine, meta-analysis, trials, vitamin B12

12/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

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Items for "meta-analysis"