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Items for "matrix metalloproteinase (MMP)"

Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation

Matrix metalloproteinases (MMPs) are critical mediators of tissue remodeling. Inappropriate regulation of MMPs causes many pathological events, including microbial invasion and inflammatory tissue damage...

Keywords: bacterial proteinase, matrix metalloproteinase (MMP), nitric oxide (NO), nuclear factor ?B (NF-?B), peroxynitrite (ONOO-), reactive nitrogen species (RNS)

11/2004 | Biological Chemistry, Walter de Gruyter
Evidence supporting proteolytic cleavage of insulin-like growth factor binding protein-1 (IGFBP-1) protein in amniotic fluid

Objective: The purpose of this study was to determine if: 1) insulin-like growth factor binding protein-1 (IGFBP-1) in amniotic fluid (AF) exhibited proteolytic cleavage in cases of intra-amniotic inflammation; and 2) if the matrix metalloproteinases (MMP-3, MMP-8, MMP-9) in AF are associated with the degradation of IGFBP-1 in AF.

Methods: AF samples (n=20) were obtained from preterm gestations with and without intra-amniotic inflammation...

Keywords: AF MMP-8, intra-amniotic inflammation, matrix metalloproteinase (MMP), preterm

07/2008 | Journal of Perinatal Medicine, Walter de Gruyter