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Items for "liver resection"

Analysis of the components of hypertransaminasemia after liver resection

Background: The increase in plasma aspartate (AST) and alanine (ALT) aminotransferase after liver resection is multifactorial, and a major problem is the difficult quantification of the impact of each factor involved.

Methods: Regression analysis of a large series of measurements for 92 hepatectomy patients was carried out to assess in detail the postoperative evolution of AST and ALT, together with related components.

Results: The best correlate of increased AST and ALT on postoperative day 1 was the duration of surgery (T-surg) (r2=0.31 and 0.29), with a lower correlation for intraoperative liver ischemia (T-isch) (r2=0.22 and 0.17, respectively; p<0.001 for all)...

Keywords: alanine aminotransferase, aspartate aminotransferase, bilirubin, liver ischemia, liver resection

03/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Plasma bilirubin correlations in non-obstructive cholestasis after partial hepatectomy

Background: The aim of this study was to provide an improved outline of the patterns and correlates of changes in plasma bilirubin after partial hepatectomy.

Methods: A large series of blood measurements and complementary variables were prospectively collected from 85 patients undergoing liver resection, and bilirubin correlations were assessed by regression analysis.

Results: Early postoperatively, the best simultaneous correlates of increasing bilirubin were the preoperative value, the duration of surgery, and the number of blood transfusions (r2=0.74, p<0.001)...

Keywords: liver dysfunction, liver ischemia, liver resection, plasma bilirubin, sepsis

11/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter