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Items for "lipid peroxidation"

Relationship between neurological outcome and early oxidative changes in erythrocytes in head injury patients

Background: Experimental data indicate that destructive oxidative events reach their peak within the first 24 h after trauma in head injury (HI) and that brain damage occurring due to this impact can be the cause of death or irreversible permanent disabilities in affected patients.

Methods: Venous blood samples were obtained from 50 HI patients within 24 h of trauma onset and from 30 age- and sex-matched normal controls (NC)...

Keywords: erythrocytes, glutathione, lipid peroxidation, outcome, reactive oxygen species

05/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals

The redox enzyme phospholipid hydroperoxide glutathione peroxidase (PHGPx) has emerged as one of the most significant selenoenzymes in mammals, corroborated by early embryonic lethality of PHGPx null mice...

Keywords: glutathione peroxidase 4, lipid peroxidation, selenoprotein, spermatogenesis, thiol peroxidase

10/2007 | Biological Chemistry, Walter de Gruyter

Preventing in vitro lipoperoxidation in the malondialdehyde-thiobarbituric assay

The malondialdehyde-thiobarbituric acid assay is widely used to study lipid peroxidation...

Keywords: butylated hydroxytoluene (BHT), high pressure liquid chromatography (HPLC), lipid peroxidation, malondialdehyde, oxidative stress

08/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Oxidative stress: potential of distinct peroxide determination systems

When reactive oxygen species attack biological structures, peroxides, which are short-lived oxidative intermediates, are generated...

Keywords: antioxidants, lipid peroxidation, oxidative stress, oxidative stress measurement, ox-LDL antibodies, peroxides

08/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Plasma homocysteine and markers for oxidative stress and inflammation in patients with coronary artery disease – a prospective randomized study of vitamin supplementation

Background: Elevated plasma levels of total homocysteine (tHcy) are associated with an increased risk of developing occlusive vascular diseases...

Keywords: cardiovascular disease, F 2-isoprostanes, homocysteine, lipid peroxidation, oxidative stress

06/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Lipid peroxidation and antioxidative status in ?-thalassemia major patients with or without hepatitis C virus infection

Background: Information pertaining to the lipid peroxidation and antioxidative status of patients with ?-thalassemic major, with or without hepatitis C virus infection, has been scanty.

Methods: We report here the results of our efforts in the evaluation of lipid peroxidative status, antioxidants, and vitamin A, E and C levels in the sera of a group of patients (n=42) with transfusion-dependent ?-thalassemic major with or without HCV infection.

Results: Firstly, plasma thiobarbituric acid reactive substance, a lipid peroxidation product, in these patients was found to be increased significantly when compared to the disease-free controls (p<0.05)...

Keywords: antioxidants, hepatitis C virus infection, iron overload, lipid peroxidation, thalassemia major

10/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Comparison of the concentration of trace metals (Ni, Zn, Co, Cu and Se), Fe, vitamins A, C and E, and lipid peroxidation in patients with prostate cancer

The anticarcinogenic and antioxidant properties of vitamins A, C, E and pro- or antioxidant properties of trace metals have recently attracted increased attention...

Keywords: lipid peroxidation, prostate cancer, trace elements, vitamins

02/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Time-level relationship between indicators of oxidative stress and Glasgow Coma Scale scores of severe head injury patients

Background: Oxidative stress is said to strongly influence the neurological recovery of patients following a severe head injury...

Keywords: ceruloplasmin, Glasgow Coma Scale, head injury, lipid peroxidation

04/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Lipid peroxidation and homocysteine levels in Behçet's disease

Background: The aim of this study was to investigate serum paraoxonase (PON1) activity in relation to homocysteine, malondialdehyde (MDA) and lipid parameters in active and inactive Behçet's disease (BD).

Methods: A total of 46 consecutive BD patients and 25 healthy control subjects were included in the present study.

Results: Serum PON1 activity in both active and inactive BD was significantly lower compared with healthy subjects (p<0.05)...

Keywords: homocysteine, lipid peroxidation, paraoxonase

09/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21

Background: It has been suggested that an increase in oxidative stress in individuals with Down syndrome (DS) may cause adverse effects in the cell membranes through the oxidation of polyunsatured fatty acids.

Methods: We examined erythrocyte malondialdehyde (MDA) levels in 100 individuals of both sexes (34 males and 66 females) with DS, aged from newborn to 29 years...

Keywords: Down syndrome, free radicals, lipid peroxidation, malondialdehyde, oxidative stress

01/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Lipid peroxidation in stroke patients

Background: Paraoxonase is high-density lipoprotein (HDL)-associated esterase/lactonase implicated to play a role in the antioxidant and anti-inflammatory properties exerted by HDL...

Keywords: antioxidants, lipid peroxidation, lipoproteins, paraoxonase, Stroke

01/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

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Items for "lipid peroxidation"