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Items for "leukemia"

Modulation of autocrine TNF-?-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogen-activated protein kinases in THP-1 monocytic cells

Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins...

Keywords: cross-talk, ERK, gelatinase B, JNK, leukemia, p38

01/2006 | Biological Chemistry, Walter de Gruyter

Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells

The BCL2 family of genes (B-cell CLL/lymphoma 2; Bcl-2) plays a pivotal role in the highly regulated process of apoptosis...

Keywords: Apoptosis, BAX, BCL2L12, caspase, FAS, leukemia, methotrexate, topotecan

12/2006 | Biological Chemistry, Walter de Gruyter

A novel application of melting curves: utility of peak area calculation for relative methylation quantification

Background: DNA methylation markers appear to be useful in cancer detection, in evaluating the prognosis associated with disease progression, and in detecting the metastatic potential of tumors.

Methods: We present an approach for relative quantification of methylated gene sequences...

Keywords: leukemia, melting curve, methylation, methylation index, peak area calculation

07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Plasma levels of tumor M2-pyruvate kinase should not be used as a tumor marker for hematological malignancies and solid tumors

It has been reported that the dimeric isoform of the enzyme pyruvate kinase M2 was overexpressed in various solid tumor cells...

Keywords: acute inflammatory reaction, dimeric isoenzyme, leukemia, lymphoma, tumor M2-pyruvate kinase (Tu M2-PK)