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Items for "latent abnormal values exclusion method"

Determination of reference intervals for 26 commonly measured biochemical analytes with consideration of long-term within-individual variation

Background: A reference interval (RI) is usually derived from a data set obtained cross-sectionally without consideration of the long-term analytical coefficient of variation (CV) (CVA) or within-individual CV (CVI).

Methods: A total of 135 healthy volunteers, 22–59 years of age, working in eight clinical laboratories in Japan participated in a study to determine RIs for 26 commonly measured biochemical analytes...

Keywords: analytical variation, between-individual variation, bootstrap method, latent abnormal values exclusion method, within-individual variation

05/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Sources of variation and reference intervals for serum cystatin C in a healthy Japanese adult population

Background: To derive reference intervals (RIs) for cystatin C (CysC), we examined sources of variation in its serum concentration by multiple regression analysis.

Methods: A total of 596 healthy subjects (30–75 years of age) who underwent an annual health check were chosen as candidate reference individuals who did not have any chronic illness requiring medication...

Keywords: age-related change, cystatin C, latent abnormal values exclusion method, multiple regression analysis, preanalytical variation

09/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter