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Items for "kallikreins"

Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more

Serine proteinases, like trypsin, can play a hormone-like role by triggering signal transduction pathways in target cells...

Keywords: hormone action, inflammation, kallikreins, protease-activated receptors, proteases, proteinases, receptors, signal transduction, trypsin

06/2006 | Biological Chemistry, Walter de Gruyter
mRNA expression analysis of human kallikrein 11 (KLK11) may be useful in the discrimination of benign prostatic hyperplasia from prostate cancer after needle prostate biopsy

Kallikrein 11 (KLK11, TLSP, hippostatin) is a member of the human kallikrein gene family, which includes PSA, KLK2 and 12 other members, all localized on chromosome 19q13.4...

Keywords: free PSA, kallikreins, PCR, prostate, prostate cancer, prostate-specific antigen, PSA, serine proteases, tumor biomarkers

06/2006 | Biological Chemistry, Walter de Gruyter
Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs)

We tested the hypothesis that human tissue kallikreins (hKs) may regulate signal transduction by cleaving and activating proteinase-activated receptors (PARs)...

Keywords: inflammation, kallikreins, receptors, serine proteinases, signal transduction, trypsin

06/2006 | Biological Chemistry, Walter de Gruyter
Kunitz-type Bauhinia bauhinioides inhibitors devoid of disulfide bridges: isolation of the cDNAs, heterologous expression and structural studies

Bauhinia bauhinoides cruzipain inhibitor (BbCI) and Bauhinia bauhinioides kallikrein inhibitor (BbKI) are cysteine and serine proteinase inhibitors structurally homologous to plant Kunitz-type inhibitors, but are devoid of disulfide bridges...

Keywords: cathepsins, cruzipain, elastase, gene, kallikreins, proteinase inhibitors

06/2005 | Biological Chemistry, Walter de Gruyter
Human kallikrein 10, a predictive marker for breast cancer

Our laboratory is involved in identifying genes that can be used as early diagnostic or prognostic markers in breast cancer...

Keywords: breast cancer, hK10, hypermethylation, kallikreins, predictive markers, serine protease

06/2006 | Biological Chemistry, Walter de Gruyter
Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung

Expression of the KLK13 and KLK14 genes was examined at the mRNA and protein levels in a cohort of 57 patients with non-small-cell lung cancer (NSCLC)...

Keywords: kallikrein-related peptidases, kallikreins, Lung Cancer, real-time RT-PCR, serine proteases, tissue microarray

06/2008 | Biological Chemistry, Walter de Gruyter