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Items for "isotretinoin"

Effect of 13-cis-retinoic acid on the genetic expression profile of human umbilical vein endothelial cells (HUVECs) determined by microarray

Background: Treatment with isotretinoin (13-cis-retinoic acid; 13-cis RA) has been associated with hypertriglyceridemia and low levels of high-density lipoprotein (HDL)-cholesterol, which are well-established cardiovascular risk factors...

Keywords: Cell adhesion, 13-cis-retinoic acid, high-density lipoprotein, human umbilical vein endothelial cell (HUVEC), isotretinoin

07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Isotretinoin therapy induces DNA oxidative damage

Background: Isotretinoin (Iso) is currently indicated for the treatment of cystic acne (CA) and is related to marked teratogenicity.

Aim: The aim of the study was to evaluate the relationship between total antioxidant status (TAS) and a serum marker of DNA oxidative damage, 8-hydroxy-2-desoxyguanosine (8-OHdG), in patients on Iso treatment.

Patients and methods: Patients with CA (n=18) were evaluated before and 45 days after Iso (0.5mg/kg per day) treatment and non-diseased controls (n=22) were tested only once...

Keywords: cystic acne, DNA damage, free radicals, 8-hydroxy-2-desoxyguanosine (8-OhdG), isotretinoin

11/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter