To investigate the effect of tiplaxtinin, designed as a synthetic inhibitor of plasminogen activator inhibitor-1 (PAI-1), on obesity, male C57Bl/6 mice (13-14 weeks old) were kept on a high-fat diet (20.1 kJ/g) for four weeks without or with addition of tiplaxtinin (PAI-039) at a dose of 2 mg/g food...
Keywords: PAI-1, obesity, adipose tissue, glucose tolerance, insulin sensitivity
12/2006 | Thrombosis and Haemostasis, SchattauerInsulin resistance and erythrocyte sedimentation rate (ESR, a non-specific marker of inflammation) are known risk factors for cardiovascular disease...
Keywords: Diabetes mellitus, obesity, inflammation, insulin sensitivity, erythrocyte sedimentation rate
00/0000 | Thrombosis and Haemostasis, SchattauerWe examined insulin sensitivity and secretion, together with the levels of selected glucoregulatory hormones, in 15 female patients with severe hypothyroidism (H) and during subsequent thyroid hormone replacement therapy (HRT) using the euglycaemic hyperinsulinaemic clamp technique...
Keywords: counter-regulatory hormones, hypothyroidism, insulin sensitivity
07/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterKeywords: glucose tolerance test, insulin indices, insulin resistance, insulin sensitivity, type 2 diabetes
07/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter