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Items for "insulin sensitivity"

Tiplaxtinin impairs nutritionally induced obesity in mice

To investigate the effect of tiplaxtinin, designed as a synthetic inhibitor of plasminogen activator inhibitor-1 (PAI-1), on obesity, male C57Bl/6 mice (13-14 weeks old) were kept on a high-fat diet (20.1 kJ/g) for four weeks without or with addition of tiplaxtinin (PAI-039) at a dose of 2 mg/g food...

Keywords: PAI-1, obesity, adipose tissue, glucose tolerance, insulin sensitivity

12/2006 | Thrombosis and Haemostasis, Schattauer
Sex-specific, independent associations of insulin resistance with erythrocyte sedimentation rate in apparently healthy subjects

Insulin resistance and erythrocyte sedimentation rate (ESR, a non-specific marker of inflammation) are known risk factors for cardiovascular disease...

Keywords: Diabetes mellitus, obesity, inflammation, insulin sensitivity, erythrocyte sedimentation rate

00/0000 | Thrombosis and Haemostasis, Schattauer
Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy

We examined insulin sensitivity and secretion, together with the levels of selected glucoregulatory hormones, in 15 female patients with severe hypothyroidism (H) and during subsequent thyroid hormone replacement therapy (HRT) using the euglycaemic hyperinsulinaemic clamp technique...

Keywords: counter-regulatory hormones, hypothyroidism, insulin sensitivity

07/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Comparability of indices for insulin resistance and insulin secretion determined during oral glucose tolerance tests

Background: Impaired insulin secretion (IS) and insulin resistance (IR) play an essential role in the pathogenesis of type 2 diabetes mellitus...

Keywords: glucose tolerance test, insulin indices, insulin resistance, insulin sensitivity, type 2 diabetes

07/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter