Items for "Ins2Akita"

Proinsulin lacking the A7-B7 disulfide bond, Ins2^Akita, tends to aggregate due to the exposed hydrophobic surface

A single mutation (C96Y) in the Ins2 gene, which disrupts the A7-B7 disulfide bond, causes the diabetic phenotype in Akita mice...

Keywords: aggregation, ?-cell dysfunction, C96Y mutation of diabetes, disulfide bond, hydrophobic surface, Ins2Akita