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innate immunity
Items for "innate immunity"
Evolution of kallikrein-related peptidases in mammals and identification of a genetic locus encoding potential regulatory inhibitors
The human kallikrein locus on chromosome 19 consists of 15 genes encoding serine proteases...
Keywords: innate immunity, prostate-specific antigen, semenogelin, serine proteinase, species specificity, WFDC domain
03/2006 | Biological Chemistry, Walter de GruyterThe insect metalloproteinase inhibitor gene of the lepidopteran Galleria mellonella encodes two distinct inhibitors
The insect metalloproteinase inhibitor (IMPI) from the greater wax moth,
Keywords: Galleria mellonella, innate immunity, insects, matrix metalloproteinases, microbial metalloproteinases, protein glycosylation
01/2007 | Biological Chemistry, Walter de GruyterDifferential production of immunoglobulin classes and subclasses by mucosal-type human B-lymphocytes exposed in vitro to CpG oligodeoxynucleotides
As B-lymphocytes play an important role in innate and adaptive immunity, we aimed to examine the effects of CpG oligodeoxynucleotides (ODNs) on purified tonsil-originating CD19+ B-cells, representing mucosal B-cells...
Keywords: antibodies, B-lymphocytes, cytokines, innate immunity, vaccination
01/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterA long and winding road: defining the biological role and clinical importance of paraoxonases
Paraoxonase-1 (PON1) is an enzyme belonging to a three-member gene family, each of which is highly conserved in mammalian evolution...
Keywords: high-density lipoproteins, innate immunity, lactonase, oxidative stress, quorum quenching, toxicology, vascular disease
09/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterHepatitis C virus (HCV) employs multiple strategies to subvert the host innate antiviral response
Hepatitis C virus (HCV) is a serious global health problem which accounts for approximately 40% of chronic liver diseases worldwide...
Keywords: hepatitis C, innate immunity, interferon signaling, pathogen-associated molecular pattern, pathogen recognition receptors, retinoic acid-inducible gene I
10/2008 | Biological Chemistry, Walter de GruyterSabotage of antiviral signaling and effectors by influenza viruses
Vertebrate cells activate multiple signaling modules upon virus infection to eliminate the invading pathogen and to prevent the establishment of a persistent infection...
Keywords: influenza virus, innate immunity, interferon, NS1 protein, RIG-I, signaling
10/2008 | Biological Chemistry, Walter de GruyterDendritic cell subtypes as primary targets of vaccines: the emerging role and cross-talk of pattern recognition receptors
Preventive vaccination is the most successful approach against infectious diseases and has a great impact on world health...
Keywords: cross-priming, cytokines, immunomodulation, innate immunity, signaling, T-cell polarization
05/2008 | Biological Chemistry, Walter de GruyterSalivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer
Salivary agglutinin (SAG), lung glycoprotein-340 (gp-340) and Deleted in Malignant Brain Tumours 1 (DMBT1) are three names for identical proteins encoded by the
Keywords: innate immunity, mucosal defence, saliva, tumour suppression
12/2007 | Biological Chemistry, Walter de Gruyter