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Items for "inhibitor"
Home treatment of haemarthroses using a single dose regimen of recombinant activated factor VII in patients with haemophilia and inhibitors. A multi-centre, randomised, double-blind, cross-over trial
The aim was to evaluate the efficacy and safety of two recombinant factor VIIa (rFVIIa) dose regimens for treating haemarthroses in patients with congenital haemophilia A or B and inhibitors...
Keywords: Recombinant FVIIa, Haemophilia, inhibitor, high-dose, home treatment
04/2006 | Thrombosis and Haemostasis, SchattauerThe efficacy of rituximab in the treatment of inhibitor-associated hemostatic disorders
Rituximab is a chimeric anti-CD20 monoclonal antibody active against normal and malignant B cells which has proven to be effective in the therapy of CD-20 positive lymphomas...
Keywords: Rituximab, inhibitor, coagulation disorders
08/2006 | Thrombosis and Haemostasis, SchattauerInhibition of inducible tumor necrosis factor-α expression by the fungal epipolythiodiketopiperazine gliovirin
TNF-α is a major pro-inflammatory cytokine that regulates further cytokine induction, especially of IL-1 and IL-6, in many human diseases including cancer, inflammation and immune disorders...
Keywords: ERK, gliovirin, IL-2 synthesis, inhibitor, NF-B, TNF- synthesis
06/2007 | Biological Chemistry, Walter de GruyterCysteine protease inhibitors reduce brain ?-amyloid and ?-secretase activity in vivo and are potential Alzheimer's disease therapeutics
?-Secretase inhibitors that lower brain ?-amyloid peptides (A?) are likely to be effective for treating Alzheimer's disease (AD)...
Keywords: A?, ?-amyloid, ?-secretase, cysteine protease, cathepsin B, inhibitor, Ac-LVK-CHO
01/2007 | Biological Chemistry, Walter de GruyterCleavage of the myristoylated alanine-rich C kinase substrate (MARCKS) by cysteine cathepsins in cells and tissues of stefin B-deficient mice
The myristoylated alanine-rich C kinase substrate (MARCKS) is a substrate of protein kinase C (PKC)...
Keywords: cathepsin, inhibitor, MARCKS, progressive myoclonus epilepsy
01/2007 | Biological Chemistry, Walter de GruyterDetermination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay
Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase (NOS)...
Keywords: dimethylarginine, endothelial dysfunction, inhibitor, NO pathway, risk factor
12/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter