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Items for "in vitro selection"

Interfering with hepatitis C virus IRES activity using RNA molecules identified by a novel in vitro selection method

Hepatitis C virus (HCV) infection is one of the world's major health problems, and the identification of efficient HCV inhibitors is a major goal...

Keywords: anti-hepatitis C virus internal ribosome entry site (HCV IRES) RNAs, catalytic RNAs, hepatitis C virus internal ribosome entry site (HCV IRES), inhibitor RNAs, in vitro selection, RNA aptamers

02/2005 | Biological Chemistry, Walter de Gruyter
Anti-innexin 2 aptamers specifically inhibit the heterologous interaction of the innexin 2 and innexin 3 carboxyl-termini in vitro

We recently demonstrated that heteromerization of innexins 2 and 3 from Drosophila melanogaster (Dm) is crucial for epithelial organization and polarity of the embryonic epidermis...

Keywords: Aptamer, Drosophila, gap junctions, innexin 2, innexin 3, in vitro selection

06/2007 | Biological Chemistry, Walter de Gruyter