Aims: To measure plasma concentrations of endothelin (ET)-1, NO metabolites (nitrate/nitrite; NOx) and 6-keto PGF1? (PGF1?) in maternal and fetal sheep blood, and to evaluate the effects of big ET-1 on hemodynamic response, blood gases and NO and 6-keto PGF1? production in near term fetal sheep.
Methods: Hemodynamic parameters were measured during infusion of big ET-1 into the carotid vein in chronically catheterized fetal sheep on day 125 of gestation...
Keywords: big endothelin-1, fetus, hypotension, 6-keto PGF1?), nitric oxide, sheep
11/2004 | Journal of Perinatal Medicine, Walter de Gruyter
Aim: To analyze the side effects of captopril, an angiotensin converting enzyme inhibitor (ACEI) in newborn and young infants.
Methods: Retrospective analysis of side effects in 43 patients with congenital heart disease after cardiac surgery treated with captopril for heart failure during a two-year period.
Results: Median age of the patients was 26 days (range 6–310 days), median weight 3.5 kg (range 1.9–7.9 kg)...
Keywords: Angiotensin converting enzyme inhibitor, Heart failure, hypotension, infant, Newborn, renal failure
09/2008 | Journal of Perinatal Medicine, Walter de Gruyter