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Items for "hypercoagulability"

Relatively increased von Willebrand factor activity after off-pump coronary artery bypass graft surgery

High shear forces can induce structural changes in the shape of the von Willebrand factor (VWF) molecule, making it more sensitive for ADAMTS-13, a specific VWF protease...

Keywords: von Willebrand factor, hypercoagulability, proteases / inhibitors, acquired coagulation disorders

01/2007 | Thrombosis and Haemostasis, Schattauer

COX-2 inhibitors and cardiovascular risk. Inferences based on biology and clinical studies

Even though non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used for a long time, the search continues for anti-inflammatory drugs with few side-effects...

Keywords: atherosclerosis, thrombosis, inflammation, hypercoagulability, coronary syndrome

10/2006 | Thrombosis and Haemostasis, Schattauer

Thrombin generation, a function test of the haemostatic-thrombotic system

By the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in plasma, with or without platelets, in an easy routine procedure at high throughput and with an acceptable experimental error (<5%)...

Keywords: thrombin generation, hypercoagulability, antithrombotics, Haemophilia

11/2006 | Thrombosis and Haemostasis, Schattauer

Use of calibrated automated thrombinography thrombomodulin to recognise the prothrombotic phenotype

There is currently no validated method to detect a prothrombotic phenotype. The question remains, can tissue factor (TF) induced thrombin generation (TG), as measured with the calibrated automated thrombinography (CAT) technique, according to Hemker et al., recognise a prothrombotic state either as such, or when the activated protein C (APC)-system is boosted with thrombomodulin (TM)? We determined the normal range of CAT-TG TM in a group of 71 healthy blood donors, in 11 healthy women using oral contraceptives (OC), and in 89 patients with a history of venous thromboembolism (VTE), divided into a group of 50 in which a prothrombotic risk factor could be found (VTEprf+) and 39 others (VTEprf-)...

Keywords: thrombin generation, thrombomodulin, hypercoagulability, calibrated automated thrombogram,venous thromboembolism