Items for "humanization"

Rational humanization of the powerful antithrombotic anti-GPIba antibody: 6B4

Fab-fragments of the monoclonal antibody 6B4, raised against human glycoprotein Iba (GPIba), have a powerful antithrombotic effect in baboons by blocking the GPIba binding site for von Willebrand factor (VWF), without significant prolongation of the skin bleeding time...

Keywords: Antithrombotic, computer modeling, humanization, glycoprotein Ib, Platelet