Cell survival under severe thermal stress requires the activity of a bi-chaperone system, consisting of the ring-forming AAA+ chaperone ClpB (Hsp104) and the DnaK (Hsp70) chaperone system, which acts to solubilize and reactivate aggregated proteins...
Keywords: AAA+ protein, chaperone, ClpB, DnaK, Hsp104, Hsp70, protein disaggregation
08/2005 | Biological Chemistry, Walter de GruyterThe HspBP1 homolog Fes1p was recently identified as a nucleotide exchange factor (NEF) of Ssa1p, a canonical Hsp70 molecular chaperone in the cytosol of
Keywords: Fes1p, Hsp70, molecular chaperone, nucleotide exchange factor, yeast
12/2006 | Biological Chemistry, Walter de Gruyter