Metabolic conversion of homocysteine (Hcy) to a chemically reactive metabolite, Hcy-thiolactone, catalyzed by methionyl-tRNA synthetase is the first step in a pathway that is suggested to contribute to Hcy toxicity in humans...
Keywords: atherosclerosis, homocysteine-thiolactone, N-homocysteine-protein autoantibodies
10/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter