Items for "HMG-CoA"

Familial hypercholesterolemia and response to statin therapy according to LDLR genetic background

Familial hypercholesterolemia is an autosomal dominant disease defined at the molecular level mainly by the presence of mutations in the low-density lipoprotein receptor gene and is characterized by elevated low-density lipoprotein cholesterol, tendon xanthomas and increased risk of early cardiovascular disease...

Keywords: cholesterol, familial hypercholesterolemia, HMG-CoA, low-density lipoprotein receptor (LDL-R), statins, therapy