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Items for "HepG2"

Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage

Aflatoxin B1 (AFB1) is a fungal toxin that has been associated with primary hepatocellular carcinoma (HCC) in humans...

Keywords: aflatoxin B1, aflatoxin B1-N7-guanine adduct, ?-carotene, DNA fragment-end labeling, HepG2, lycopene, p53 tumor suppressor gene

01/2006 | Biological Chemistry, Walter de Gruyter
Binding of aflatoxins to the 20S proteasome: effects on enzyme functionality and implications for oxidative stress and apoptosis

Aflatoxins (AF) are contaminants of improperly stored foods; they are potent genotoxic and carcinogenic compounds, exerting their effects through damage to DNA...

Keywords: aflatoxin, Apoptosis, HepG2, oxidative stress, proteasome, proteolytic activity

01/2007 | Biological Chemistry, Walter de Gruyter